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114, rue Édouard-Vaillant
94805 Villejuif Cedex - France


Tel : +33 (0)1 42 11 42 11


Gustave Roussy n'assure que les urgences des patients pris en charge à l'Institut.
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1er centre de lutte contre le cancer en Europe, 3 000 professionnels mobilisés

Générations et Santé

Gianluca Severi

Sabine Moreira Faria
Tél.: +33 (0)1 42 11 51 63
Fax : +33 (0)1 42 11 40 00

Espace Maurice Tubiana, Niveau -1

Frise de présentation (bandeau): 
Générations et Santé

En date de novembre 2019, les données de la cohorte E3N-E4N ont permis la publication de plus de 200 articles scientifiques.

Voici une sélection d’une vingtaine de publications significatives.

  • Fagherazzi G, El Fatouhi D, Fournier A, Gusto G, Mancini FR, Balkau B, Boutron-Ruault MC, Kurth T, Bonnet F. Associations Between Migraine and Type 2 Diabetes in Women: Findings From the E3N Cohort Study. JAMA Neurol. 2019 Mar 1;76(3):257-263.
  • Mahamat-Saleh Y, Cervenka I, Al Rahmoun M, Savoye I, Mancini FR, Trichopoulou A, Boutron-Ruault MC, Kvaskoff M. Mediterranean dietary pattern and skin cancer risk: A prospective cohort study in French women. Am J Clin Nutr. 2019 Oct 1;110(4):993-1002.
  • Ongono JS, Dow C, Gambaretti J, Severi G, Boutron-Ruault MC, Bonnet F, Fagherazzi G, Mancini FR. Dietary exposure to brominated flame retardants and risk of type 2 diabetes in the French E3N cohort. Environ Int. 2019 Feb;123:54-60.
  • Touillaud M, Gelot A, Mesrine S, Bennetau-Pelissero C, Clavel-Chapelon F, Arveux P, Bonnet F, Gunter M, Boutron-Ruault MC, Fournier A. Use of dietary supplements containing soy isoflavones and breast cancer risk among women aged >50 y: a prospective study. Am J Clin Nutr. 2019 Mar 1;109(3):597-605.
  • Fournier A, Mesrine S, Gelot A, Fagherazzi G, Baglietto L, Clavel-Chapelon F, Boutron-Ruault MC, Chabbert-Buffet N. Use of Bisphosphonates and Risk of Breast Cancer in a French Cohort of Postmenopausal Women. J Clin Oncol. 2017 Oct 1;35(28):3230-3239.
  • Cadeau C, Fournier A, Mesrine S, Clavel-Chapelon F, Fagherazzi G, Boutron-Ruault MC. Vitamin C supplement intake and postmenopausal breast cancer risk: interaction with dietary vitamin C. Am J Clin Nutr. 2016 Jul;104(1):228-34.
  • Lajous M, Rossignol E, Fagherazzi G, Perquier F, Scalbert A, Clavel-Chapelon F, Boutron-Ruault MC. Flavonoid intake and incident hypertension in women. Am J Clin Nutr. 2016 Apr;103(4):1091-8.
  • Cadeau C, Fournier A, Mesrine S, Clavel-Chapelon F, Fagherazzi G, Boutron-Ruault MC. Interaction between current vitamin D supplementation and menopausal hormone therapy use on breast cancer risk: evidence from the E3N cohort. Am J Clin Nutr. 2015 Oct;102(4):966-73.
  • Kvaskoff M, Bijon A, Mesrine S, Vilier A, Baglietto L, Fournier A, Clavel-Chapelon F, Dossus L, Boutron-Ruault MC. Association between melanocytic nevi and risk of breast diseases: The French E3N prospective cohort. PLoS Med. 2014 Jun 10;11(6):e1001660.
  • Lajous M, Bijon A, Fagherazzi G, Rossignol E, Boutron-Ruault MC, Clavel-Chapelon F. Processed and unprocessed red meat consumption and hypertension in women. Am J Clin Nutr. 2014 Sep;100(3):948-52.
  • Dossus L, Kvaskoff M, Bijon A, Engel P, Verdebout J, Fervers B, Boutron-Ruault MC, Clavel-Chapelon F, Mesrine S. Latitude and ultraviolet radiation dose in the birthplace in relation to menarcheal age in a large cohort of French women. Int J Epidemiol. 2013 Apr;42(2):590-600.
  • Lajous M, Tondeur L, Fagherazzi G, de Lauzon-Guillain B, Boutron-Ruault MC, Clavel-Chapelon F. Processed and Unprocessed Red Meat Consumption and Incident Type 2 Diabetes Among French Women. Diabetes Care. 2012 Jan;35(1):128-30.
  • Morois S, Mesrine S, Besemer F, Josset M, Clavel-Chapelon F, Boutron-Ruault MC. Risks of colon and rectal adenomas are differentially associated with anthropometry throughout life: the French E3N prospective cohort. Int J Epidemiol. 2011 Oct;40(5):1269-79.
  • de Lauzon-Guillain B, Balkau B, Charles MA, Romieu I, Boutron-Ruault MC, Clavel-Chapelon F. Birth weight, body silhouette over the life course and incident diabetes in 91,453 middle-aged women from the French E3N cohort. Diabetes Care. 2010 Feb;33(2):298-303.
  • Jantchou P, Morois S, Clavel-Chapelon F, Boutron-Ruault MC, Carbonnel F. Animal Protein Intake and Risk of Inflammatory Bowel Disease: The E3N Prospective Study. Am J Gastroenterol. 2010 Oct;105(10):2195-201.
  • Fournier A, Boutron-Ruault MC, Clavel-Chapelon F. Breast cancer and hormonal therapy in postmenopausal women. N Engl J Med. 2009 May 28;360(22):2366; author reply 2366-7.
  • Kvaskoff M, Mesrine S, Clavel-Chapelon F, Boutron-Ruault MC. Endometriosis risk in relation to naevi, freckles and skin sensitivity to sun exposure: the French E3N cohort. Int J Epidemiol. 2009 Aug;38(4):1143-53.
  • Fournier A, Fabre A, Mesrine S, Boutron-Ruault MC, Berrino F, Clavel-Chapelon F. Use of different postmenopausal hormone therapies and risk of histology- and hormone receptor-defined invasive breast cancer. J Clin Oncol. 2008 Mar 10;26(8):1260-8.
  • Lajous M, Boutron-Ruault MC, Fabre A, Clavel-Chapelon F, Romieu I. Carbohydrate intake, glycemic index, glycemic load, and risk of postmenopausal breast cancer in a prospective study of French women. Am J Clin Nutr. 2008 May;87(5):1384-91.
  • Kvaskoff M, Mesrine S, Fournier A, Boutron-Ruault MC, Clavel-Chapelon F. Personal history of endometriosis and risk of cutaneous melanoma in a large prospective cohort of French women. Arch Intern Med. 2007 Oct 22;167(19):2061-5.
  • Touillaud MS, Thiebaut AC, Fournier A, Niravong M, Boutron-Ruault MC, Clavel-Chapelon F. Dietary lignan intake and postmenopausal breast cancer risk by estrogen and progesterone receptor status. J Natl Cancer Inst. 2007;99:475-86.
  • Touvier M, Kesse E, Clavel-Chapelon F, Boutron-Ruault MC. Dual Association of beta-carotene with risk of tobacco-related cancers in a cohort of French women. J Natl Cancer Inst. 2005;97(18):1338-44.
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