Adresse

Gustave Roussy
114, rue Édouard-Vaillant
94805 Villejuif Cedex - France

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Tel : +33 (0)1 42 11 42 11

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GUSTAVE ROUSSY
1er centre de lutte contre le cancer en Europe, 3 000 professionnels mobilisés

Dynamique de la chromatine et métabolisme dans le cancer

Responsables
Dr Yegor Vassetzky
E-mail

Svetlana Dokudovskaya
E-mail
 

 

Frise de présentation (bandeau): 
Dynamique de la chromatine et métabolisme dans le cancer

Publications majeures

  • Shmakova, A, Lomov, N., Viushkov, V., Tsfasman, T.,  Kozhevnikova, Y., Sokolova, D., Pokrovsky, V., Syrkina, M., Germini, D., Rubtsov, M.,  and VASSETZKY, Y.S. (2022) Cell models with inducible oncogenic translocations allow to evaluate the potential of drugs to favor secondary translocations. Cancer Communications, DOI: 10.1002/cac2.12370
  • Karpukhina, A., Galkin, I., Ma, Y., Dib, C., Zinovkin, R., Pletjushkina, O., Chernyak, B., Popova, E. and VASSETZKY, Y.S. (2021) Analysis of genes regulated by DUX4 via oxidative stress reveals potential therapeutic targets for treatment of facioscapulohumeral dystrophy. Redox Biology, 43:102008 DOI: 10.1016/j.redox.2021.102008
  • Karpukhina, A., Tiukacheva, E., Dib, C., and VASSETZKY, Y.S. (2021) Control of DUX4 Expression in Facioscapulohumeral Muscular Dystrophy and Cancer. Trends in Molecular Medicine, 27:588-601 DOI: 10.1016/j.molmed.2021.03.008
  • Ulianov S.V., Zakharova V.V., Galitsyna A.A., Kos P.I., Polovnikov K.E., Flyamer I.M., Mikhaleva E.A., Khrameeva E.E., Germini D., Logacheva M.D., Gavrilov A.A., Gorsky A.S., Nechaev S.K., Gelfand M.S., VASSETZKY Y.S., Chertovich A.V., Shevelyov Y.Y., Razin S.V. (2021) The order and stochasticity in the folding of individual genomes. Nature Communications, 12:41 DOI: 10.1038/s41467-020-20292-z
  • Iarovaia, O.V., Minina, E.P., Sheval, E.V., Dokudovskaya, S.S., Razin, S.V. and VASSETZKY, Y.S. (2019) Nucleolus: organizing the functioning of the genome. Trends in Cell Biology, DOI: 10.1016/j.tcb.2019.04.003
  • Harrington CT, Sotillo E, Robert A, Hayer KE, Bogusz AM, Psathas J, Yu D, Taylor D, Dang CV, Klein P, Hogarty MD, Geoerger B, El-Deiry WS, Wiels J, Thomas-Tikhonenko A. (2019) Transient stabilization, rather than inhibition, of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma. Leukemia 33:2429-2441 DOI: 10.1038/s41375-019-0454-4
  • El-Amine, R., Germini, D., Zakharova V.V., Tsfasman, T., Sheval, E.V., Louzada, R.A.N., Dupuy, C., Hamade, A., Najjar, F., Bilhou-Nabera, C., Oksenhendler, E., Lipinski M., Chernyak, B.V. and VASSETZKY, Y.S. (2018) HIV-1-Tat protein induces DNA damage in human peripheral blood B-lymphocytes via mitochondrial ROS production. Redox Biology, 15:97-108 DOI: 10.​1016/​j.​redox.​2017.​11.​024
  • Germini, D., Tsfasman, T., Klibi M., Pichugin, A., El-Amine, R.,  Iarovaia, O., Bilhou-Nabera, C., Subra, F., Bou Saada, Y., Sukhanova, A., Boutboul, D., Raphaël, M.,  Wiels, J, Razin, S., Bury-Moné, S., Oksenhendler, E., Lipinski M., and VASSETZKY, Y.S. (2017) The HIV-1 Tat protein induces MYC  relocalization next to IGH in normal B-cells. Leukemia, 31:2515-2522 DOI: 10.1038/leu.2017.10
  • Allinne J., Pichugin A.,  Iarovaia O.,  Klibi M., Barat A., Zlotek-Zlotkiewicz E., Markozashvili D., Petrova N.,  Camara-Clayette V.,  Ioudinkova E., Wiels, J, Razin, S., Ribrag V., Lipinski M., and VASSETZKY, Y.S. (2014) Perinucleolarrelocalization and nucleolin as crucial events in the transcriptional activation of key genes in mantle cell lymphoma. Blood. 123:2044-53 DOI:10.1182/blood-2013-06-510511
  • Loissell-Baltazar YA and DOKUDOVSKAYA S. SEA and GATOR 10 years later. Cells. 2021 Oct 8;10(10):2689 doi: 103390/cells11030474
  • Akbay B, Germini D, Bissenbaev AK, Musinov Y, Sheval EV, Vassetzky Y, DOKUDOVSKAYA S. HIV-1 Tat Activates Akt/mTORC1 Pathway and AICDA Expression by Downregulating Its Transcriptional Inhibitors in B Cells. Int J Mol Sci. 2021 Feb 4; 22(4): 1588. doi: 10.3390/ijms22041588
  • Akbay B, Shmakova A, Vassetzky Y, DOKUDOVSKAYA, S. Modulation of mTORC1 Signalling Pathway by HIV-1. Cells. 2020 Apr 28;9(5):1090. doi: 10.3390/cells9051090. PMID: 32354054. Review.
  • Ma Y., Moors A., Camougrand N., DOKUDOVSKAYA, S. The SEACIT complex is involved in the maintenance of vacuole-mitochondria contact sites and controls mitophagy. Cell Mol Life Sci. 2019 Apr;76(8):1623-1640. doi: 10.1007/s00018-019-03015-6.
  • Ma, Y., Vassetsky, Y.S., DOKUDOVSKAYA, S. mTORC1 pathway in DNA damage response. BBA Molecular Cell Research, 2018, 1865(9):1293-1311. doi: 10.1016/j.bbamcr.2018.06.011
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