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Gustave Roussy
114, rue Édouard-Vaillant
94805 Villejuif Cedex - France

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Tel : +33 (0)1 42 11 42 11

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GUSTAVE ROUSSY
1er centre de lutte contre le cancer en Europe, 3 000 professionnels mobilisés

Mécanismes de réparation de l'ADN et cancérogenèse.

Responsable :
Dr Murat Saparbaev
Tél.: +33 (0)1 42 11 54 04

Pavillon de recherche 2, Niveau 4

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Frise de présentation (bandeau): 
Mécanismes de réparation de l'ADN et cancérogenèse.

Publications majeures

  • Matkarimov, B.T., Zharkov, D.O., and SAPARBAEV, M.K. (2019) Mechanistic insight into the role of Poly(ADP-ribosyl)ation in DNA topology modulation and response to DNA damage. Mutagenesis, Nov 29. pii: gez045. doi: 10.1093/mutage/gez045/5646155.
  • Bazlekowa-Karaban, M., Prorok, P., Baconnais, S., Taipakova, S., Akishev, Z., Zembrzuska, D., Popov, A.V., Endutkin, A.V., GROISMAN, R., ISHCHENKO, A.A. Matkarimov, B.T., Bissenbaev, A., Le Cam, E., Zharkov, D.O., Tudek, B. and SAPARBAEV, M. (2019) Mechanism of stimulation of DNA binding of the transcription factors by human apurinic/apyrimidinic endonuclease 1, APE1. DNA Repair (Amst), 82, 102698. DOI: 10.1016/j.dnarep.2019.102698.
  • Zarkovic, G., Belousova, E. A., Talhaoui, I., Saint-Pierre, C., Kutuzov, M. M., Matkarimov, B. T., Biard, D., Gasparutto, D., Lavrik, O. I., and ISHCHENKO, A.A. (2018) Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation, Nucleic Acids Res 46, 2417-2431.
  • Gattolliat CH, COUVE, S., Meurice, G., Orear, C., Droin, N., Chiquet, M., Ferlicot, S., Verkarre, V., Vasiliu, V., Molinie, V., Mejean, A., Dessen, P., Giraud, S., Bressac-De-Paillerets, B., Gardie, B., Tean Teh, B., RICHARD. S., GAD, S. 2018. Integrative analysis of deregulated microRNAs and mRNAs in multiple recurrent synchronized renal tumors of von Hippel-Lindau patients. Int J Oncol 53: 1455-1468.
  • Martin, P.R., COUVÉ, S., Zutterling, C., Albelazi, M.S., Groisman, R., Matkarimov, B.T., Parsons, J.L., Elder, R.H. and SAPARBAEV, M.K. (2017) The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure. Scientific Reports, 7, 17438.
  • Talhaoui, I., Lebedeva, N. A., Zarkovic, G., Saint-Pierre, C., Kutuzov, M. M., Sukhanova, M. V., Matkarimov, B. T., Gasparutto, D., SAPARBAEV, M.K., Lavrik, O. I., and ISHCHENKO, A. A. (2016) Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro. Nucleic Acids Res., 44, 9279-9295.
  • Benusiglio PR*, COUVÉ, S*., Gilbert-Dussardier, B., Deveaux, S., Le Jeune, H., Da Costa, M., Fromont, G., Memeteau, F., Yacoub, M., Coupier, I., Leroux, D., Mejean, A., Escudier, B., Giraud, S., Gimenez-Roqueplo, A. P., Blondel, C., Frouin, E., Teh, B. T., FERLICOT, S., Bressac-de Paillerets, B., RICHARD. S., and GAD, S. (2015) A germline mutation in PBRM1 predisposes to renal cell carcinoma. Journal of Medical Genetics 52: 426-430.
  • Talhaoui, I., COUVE, S., Gros, L., ISHCHENKO, A.A., Matkarimov, B. and SAPARBAEV, M.K. (2014) Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands. Nucleic Acids Res., 42(10), 6300-6313.
  • COUVÉ, S., Ladroue, C., Laine, E., Mahtouk, K., Guegan, J., Gad, S., Le Jeune, H., Le Gentil, M., Nuel, G., Kim, W. Y., Lecomte, B., Pages, J. C., Collin, C., Lasne, F., Benusiglio, P. R., Bressac-de Paillerets, B., Feunteun, J., Lazar, V., Gimenez-Roqueplo, A. P., Mazure, N. M., Dessen, P., Tchertanov, L., Mole, D. R., Kaelin, W., Ratcliffe, P., RICHARD S & Gardie B. (2014) Genetic evidence of a precisely tuned dysregulation in the hy poxia signaling pathway during oncogenesis. Cancer Research 74: 6554-6564.
  • Prorok, P., Alili, D., Saint-Pierre, C., Gasparutto, D., Zharkov, D.O., ISHCHENKO, A.A., Tudek, B. and SAPARBAEV, M.K. (2013) Uracil in duplex DNA is a substrate for the nucleotide incision repair pathway in human cells. Proc. Natl. Acad. Sci. U.S A., 110(39), E3695-3703.
  • Mazouzi, A., Vigouroux, A., Aikeshev, B., Brooks, P.J., SAPARBAEV, M., Morera, S. and A.A. ISHCHENKO (2013) Insight into mechanisms of 3’-5’ exonuclease activity and removal of bulky 8,5’-cyclopurine adducts by AP endonucleases. Proc. Natl. Acad. Sci. U.S.A. 110(33):E3071-3080.
  • RICHARD, S., Gardie, B., COUVE, S., and GAD, S. (2013) Von Hippel-Lindau: How A Rare Disease Illuminates Cancer Biology. Seminars In Cancer Biology 23: 26-37.
  • ISCHENKO, A.A. and SAPARBAEV, M.K. (2002) Alternative nucleotide incision repair pathway for oxidative DNA damage. Nature, 415, 183-187.

 

 

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