Impact of tumor microenvironment on tumor resistance and its role in shaping tumor plasticity and stroma reactivity

This group belongs to the UMR 1186 - Integrative tumor immunology and immunotherapy

Lab members

• Karim Fizazi (PU-PH Univ. Paris-Saclay)
• Yohann Loriot (MD-PhD, GR)
• Anne Chauchereau (CRCN-HDR INSERM)
• Virginie Quidville (Research Engineer, GR)
• Déborah Bellet (Chargée d’études, GR)
• Ludovic Bigot (Engineer, GR)
• Sandrine Agoussi (Technician, GR)
• Jonathan Sabio (Technician, GR)
• Guiseppina Claps (Post-Doctoral fellow, GR)
• Ramdane Guemiri (Post-Doctoral fellow, GR)
• Shensi Shen (Post-Doctoral fellow, GR)
• Michaël Cerezo (Post-Doctoral fellow, GR)

Major publications

• Shen S et al. An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells. Nat Commun. 2019; 10(1):5713.
• Cerezo M, Guemiri R et al. Translational control of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma Nat Med. 2018 (12):1877-1886

Adaptative resistance to anticancer-therapies

This group belongs to the UMR 981 - Molecular predictors and new targets in oncology

Lab members

• Ken Olaussen (MCU Univ. Paris-Saclay, HDR)
• Françoise Farace (Ingénieure IGR, HDR)
• Benjamin Besse (PU-PH Univ. Paris-Saclay)
• Christophe Massard (PU-PH Univ. Paris-Saclay)
• David Planchard (MD IGR)
• Patrycja Pawlikowska (Ingénieure de recherche IGR)
• Floriane Brayé (Ingénieure d’études IGR)
• Marianne Oulhen (Ingénieure d’études IGR)
• Pauline Tesson (Technicienne IGR)
• Agathe Aberlenc (Technicienne IGR)
• Natalia Pinzon (Post-Doctorante IGR)

Major publications

1: Facchinetti F, Hollebecque A, Bahleda R, Loriot Y, Olaussen KA, Massard C, Friboulet L. Facts and New Hopes on Selective FGFR Inhibitors in Solid Tumors. Clin Cancer Res. 2019 Oct 4. doi: 10.1158/1078-0432.CCR-19-2035. [Epub ahead of print] Review. PubMed PMID: 31585937.

Genetic tumor adaptation to kinase inhibitors

This group belongs to the UMR 981 - Molecular predictors and new targets in oncology

The research groups of Gustave Roussy are gathered in 12 research units:

UMR 1279 - Tumor cell dynamics

UMR 1287 - Hematopoietic stem cells and the development of myeloid malignancies

At the apex of the hematopoietic tissue, hematopoietic stem cells (HSCs) self-renew and give rise to all blood cell lineages. The tightly regulated mechanisms involved in normal hematopoiesis include a number of intrinsic factors, such as transcription factors & epigenetic marks, and extrinsic factors such as surrounding cells of the niche and the cytokines they produce.