UMR 1030 - Molecular Radiotherapy and Therapeutic Innovation

UMR 1186 - Integrative tumor immunology and immunotherapy

Our laboratory highlighted several constitutive elements of the tumor environment (TME) involved in the regulation of antitumor T-cell response, in particular:

Centre for research in epidemiology and population health

The Centre for Research in Epidemiology and Population Health (CESP) is one of the largest French centres for training and research in Public Health.   

It is linked to Inserm, the Paris-Saclay University and the University of Versailles Saint Quentin.

3 of the CESP groups are based on the Gustave Roussy site:

UMR S1138 « Centre de Recherche des Cordeliers »

The UMR S1138, Cordeliers Research Centre, is under the aegis of the University of Paris Descartes, Inserm and the Pierre and Marie Curie University (UPMC) and has links with CNRS and the Ecole Pratique des Hautes Etudes (EPHE) (Practical Higher Studies School).

One of the teams from the UMR S1138, « Metabolism, cancer and immunity » is located on the Gustave Roussy site. It is directed by Professor Guido Kroemer.

Lab members

• Brigitte Bressac de Paillerets, PhD, PharmD, Geneticist
• Aude Robert, PhD, Research engineer
• Justine Del Rio, Technician and lab manager
• Julia Gilaizeau, Technician
• Elisa Stubbs, PhD candidate
• Sophie Lachaud, PhD candidate
• Assaf Alassaf, M2
• Mélanie Bennaroch, Technician

Major publications

• Golan, T., Parikh, R., Jacob, E., Vaknine, H., Zemser-Werner, V., Hershkovitz, D., Malcov, H., Leibou, S., Reichman, H., Sheinboim, D., Percik, R., Amar, S., Brenner, R., Greenberger, S., Kung, A., Khaled, M., and Levy, C. (2019) Adipocytes sensitize melanoma cells to environmental TGF-beta cues by repressing the expression of miR-211. Sci Signal 12

Oncogenesis and tumour progression of melanoma group

This group belongs to the UMR 1279 - Tumor cell dynamics

In our group we are studying in parrallel:

• The biology of melanocytes which are pigment producing cells responsible for skin color
• The biology of cutaneous melanoma, which derives fromm melanocytes.

Using a comprehensive approach, we strive to identify mutations responsible for melanoma transformation and genes involved in metastasis.

Tumour Immunology and anti-cancer immunotherapy unit

This unit is an Inserm, Gustave Roussy and Paris-Saclay University Mixed Research Unit.

The unit "Tumour immunology and anti-cancer immunotherapy" consists of two groups:

Molecular predictors and new targets in oncology

Directed by Prof.Fabrice André, this Mixed Research Unit (Inserm - Gustave Roussy - University of Paris Sud) is a multiple team unit:

UMR 1170 - Transcriptional and epigenetic control of Malignant Hematopoiesis