Host-tumor interactions in Head and Neck carcinomas

This group belongs to the UMR 9018 - Metabolic and systemic aspects of oncogenesis for novel therapeutic approaches (Metsy)

Genome integrity, immune response and cancer

This group belongs to the UMR 9019 Genome Integrity and Cancers.

• Svetlana Dokudovskaya, DR2 CNRS
• Yegor Vassetzky, DR1 CNRS
• Joëlle Wiels, DREM CNRS
• Marc Lipinski, DREM CNRS
• Yahir Alberto Loissel Baltazar, PhD student (Université Paris-Saclay)
• Anna Shmakova, PhD student (Université Paris-Saclay)
• Zhenrui Pan, PhD student (Université Paris-Saclay-CSC)
• Anna Karpukhina, PhD student (Université Paris-Saclay)
• Junyi Feng,  PhD student (Université Paris-Saclay-CSC)
• Haoran Chai, PhD student (Université Paris-Saclay-CSC)

Major publications

• Shmakova, A, Lomov, N., Viushkov, V., Tsfasman, T.,  Kozhevnikova, Y., Sokolova, D., Pokrovsky, V., Syrkina, M., Germini, D., Rubtsov, M.,  and VASSETZKY, Y.S. (2022) Cell models with inducible oncogenic translocations allow to evaluate the potential of drugs to favor secondary translocations. Cancer Communications, DOI: 10.1002/cac2.12370

Chromatindynamics and metabolism in cancer

This group belongs to the UMR 9018 - Metabolic and systemic aspects of oncogenesis for novel therapeutic approaches (Metsy)

We are working on the founding events in oncogenesis. Our approach allows us to search for early biomarkers of cancers and develop cancer-preventive approaches.

Lab members

Thierry Heidmann, DR1 CNRS, Group leader

Chercheurs

• Marie  Dewannieux, CR2 INSERM
• ANNE  Dupressoir, CR1 INSERM
• Cécile  Esnault, CR1 INSERM
• Odile  Heidmann, CR1 CNRS
• Christian  Lavialle, CR1 CNRS
• Géraldine  Schlecht-Louf, MC Univ Paris-Sud XI

Post-doctorants et étudiants

Publications

• Risks linked to endogenous retroviruses for vaccine production: a general overview. Dewannieux M, Ribet D, Heidmann T. 
  Biologicals. 2010 May;38(3):366-70. PMID: 20335054 
• Retroviral infection in vivo requires an immune escape virulence factor encrypted in the envelope protein of oncoretroviruses. Schlecht-Louf G, Renard M, Mangeney M, Letzelter C, Richaud A, Ducos B, Bouallaga I, Heidmann T. 
  Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3782-7. PMID: 20142478 

Endogenous retroviruses and retroid elements in
higher eukaryotes

The group is interested in retro-elements and, more particularly, in infectious and endogenous human retroviruses. We have identified a highly-conserved domain on the envelope proteins of these elements, which possess immunosuppressive properties and play an essential role in:

Lab members

Researchers / Teacher-researchers / PH:

• Jacques GRILL (MD, PhD, HDR)
• Marie-Anne DEBILY (MCU, Univ. d’Evry Val d’Essonne, HDR)
• David CASTEL (CRCN, INSERM, HDR)
• Gilles VASSAL (PU-PH, Univ. Paris-Saclay, HDR)
• Marco BRUSCHI (Postdoctorant, GR)
• Christelle DUFOUR (PH, GR)
• Léa GUERRINI (PH, GR)

Engineers / Technicians: 

Major publications

• 1: Werbrouck C, Evangelista CCS, Lobón-Iglesias MJ, Barret E, Le Teuff G, Merlevede J, Brusini R, Kergrohen T, Mondini M, Bolle S, Varlet P, Beccaria K, Boddaert N, Puget S, Grill J, Debily MA, Castel D. TP53 Pathway Alterations Drive Radioresistance in Diffuse Intrinsic Pontine Gliomas (DIPG). Clin Cancer Res. 2019 Nov 15; 25(22):6788-6800. doi: 10.1158/1078-0432.CCR-19-0126.