Molecular predictors and new targets in oncology
Directed by Prof.Fabrice André, this Mixed Research Unit (Inserm - Gustave Roussy - University of Paris Sud) is a multiple team unit:
- Molecular caracterization of breast and gynecologic cancers (Fabrice Andre),
- Genetic tumor adaptation to kinase inhibitors (Luc Friboulet),
- Genomics and Oncogenesis of pediatric Brain Tumors (Jacques Grill),
- Laboratory of Cancer Genomics (Sergey Nikolaev),
- Adaptive resistance mechanisms to anticancer treatments (Caroline Robert),
- Chromatin remodeling, DNA repair and epigenetic (Sophie Postel-Vinay)
The Unit is composed of 80 FTE including five University professors, three assistant or associate professors, five Inserm researchers and three CNRS researchers.
The aim of the Unit is to identify new targets that drive cancer progression, identify molecular predictors and to develop targeted therapies.
The questions addressed by the unit members are:
- the characterization of molecular events driving the evolution from primary tumors to metastases;
- interaction between angiogenesis and anti-tumor immunity;
- mechanisms of resistance to kinases targeted therapy;
- translation and regulation of proteostasis in drug-resistance;
- vulnerabilities of diffuse midline glioma;
- the non-coding mutational landscape of Basal cell carcinoma.
The identification of candidate targets is done through large scale molecular analyses of patient cohorts, ideally from prospective clinical trials.
The unit is integrated in the same precision medicine building as translational research platform, bioinformatics platform and the biostatistics team of the CESP research center. Through Gustave Roussy and UNICANCER, the Unit has access to samples from clinical trials in which the unit members are involved as investigators.