Translational Research in Hematology

The platform integrates advanced technologies in automated cell biology and high-content discovery to study the molecular mechanisms of cellular stress, regulated cell death, and immunogenic cell death. The infrastructure combines robotic sample handling, automated microscopy, multiplexed fluorescence imaging, and computational analysis pipelines to perform high-throughput phenotypic screening. A dedicated team of engineers and scientists ensures the optimization of automated workflows and data analysis environments.
The platform enables the systematic characterization of cellular stress responses induced by pharmacological agents, genetic perturbations, or environmental stimuli, with a particular focus on endoplasmic reticulum stress, oxidative stress, mitochondrial dysfunction, and autophagy. Live-cell imaging combined with multiparametric analyses enables dynamic monitoring of stress responses and the expression of danger signals.
The CCHD platform plays a central role in the study of immunogenic cell death and in the identification of inducers capable of stimulating antitumor immunity. Co-culture assays and artificial intelligence-assisted analyses complement these approaches for mechanistic and translational studies in oncology.
Finally, the platform provides scalable computational pipelines for image processing, feature extraction, and AI-assisted integrative data analysis, enabling the generation of robust and reproducible multidimensional datasets for translational cancer research.

Cyril QUIVORON - Platform Operations Manager
Research Engineer or equivalent
Employer: Gustave Roussy

DE BOTTON Stéphane - Platform Scientific Manager
University Associate Professor and Hospital Practitioner
Employer: Paris-Saclay University

BENLARBI Yasmine 
Research Technician or equivalent
Employer: Gustave Roussy

SABOURIN COUSIN Marjorie
Research Technician or equivalent
Employer: Gustave Roussy