Welcome to the new Gustave Roussy website
A new website designed to offer you a simpler, clearer, and more intuitive experience. Patients, caregivers, healthcare professionals, and donors: find information, news, and services more easily.
XenTech Signs Strategic Collaboration Agreement with Gustave Roussy Cancer Center
On
Evry, France, March 27, 2019
XenTech Signs Strategic Collaboration Agreement with Gustave Roussy Cancer Center
Specialized CRO and Leading Cancer Center to Develop New Panel of Patient-Derived Xenograft (PDX) Models from Patients with Acquired Resistance to Last-Generation Targeted Drugs in Oncology
XenTech SAS, a company specialized in the development and sale of preclinical research services to foster the development of oncology drugs, today announces a strategic collaboration with Gustave Roussy, Europe's leading cancer center. This co-operation, the first of its kind for XenTech, will focus on the development of a collection of tumor explant models from patients who developed acquired resistance to targeted therapies following initial response. These PDX models will be used in Gustave Roussy’s oncology R&D programs, as well as being added to XenTech’s existing PDX platform for translational oncology research projects for academic and industry customers.
Patients with tumors that harbor specific driver molecular alterations benefit from targeted therapies, but responses are generally short-lived due to the emergence of adaptive/secondary resistance. Between 2015 and 2020 the MATCH-R trial led by Gustave Roussy (NCT02517892) will have enrolled 600 patients treated with targeted therapies. Biopsies will be used to generate PDX models, obtained from 300 patients who have developed resistance following initial response. The MATCH-R PDX platform will be regularly upgraded with new models, providing a unique resource in unravelling the mechanisms involved in acquired resistance to targeted therapies and testing novel therapeutic strategies to circumvent or delay the emergence of resistance.
“We are delighted to collaborate with Gustave Roussy on this unique and ambitious program,” said Jean-Gabriel Judde, CSO and president of XenTech. “These new models will expand XenTech’s bank of PDX models with focus on the advanced drug-resistant setting. The MATCH-R PDX platform will enable a better understanding of acquired resistance to last-generation targeted therapies, providing clinically relevant models to perform preclinical POC studies, translating into increased patient survival. Full clinical and molecular annotation will enable model selection for testing innovative therapies, investigating new and existing pathways, and identifying biomarkers.”
“Understanding the mechanisms of acquired resistance to novel targeting agents is crucial in providing optimal care to cancer patients,” said Benjamin Besse, head of the department of medical oncology at Gustave Roussy and principal investigator of the MATCH-R clinical trial. “This strategic collaboration with XenTech, a renowned expert in PDX development and in vivo pharmacological studies, is a major asset for Gustave Roussy’s precision medicine program. There is no doubt that these clinically relevant models will speed-up the development of novel therapeutic agents leading to extended clinical benefit for metastatic cancer patients.”
XenTech will participate in American Association Cancer Research Annual Meeting, Friday, March 29 - Wednesday, April 3, 2019, in Atlanta, GA.
▶
xentech-gustaveroussy-press-release-27-03-2019-en.pdf
Press contact
If you are a journalist and have a question, please contact:
Claire Parisel or Léona Pinto
Tel. +33 1 42 11 50 59
Tel. +33 1 42 11 63 59
Mob. +33 6 17 66 00 26
Email
The Media Team cannot respond to patient inquiries.
Last press releases
-
INTERCEPTION: The national pilot program for personalized cancer prevention among individuals at increased risk of cancer enters its operational phase with the enrollment of the first patients
The Interception program has reached a new milestone with the enrollment of its first patients as part of the national Article 51 pilot program. Rolled out over four years across seven healthcare facilities, this pilot program is designed to evaluate an innovative model for personalized cancer prevention and screening.
-
After a breast cancer diagnosis, how can treatment be started more quickly?
Gustave Roussy is launching a new care pathway designed to accelerate the management of women recently diagnosed with breast cancer. It brings together, in a single day, the radiology examinations, blood tests, and oncology consultation required to initiate treatment. This new pathway complements the Institute’s rapid breast care offering. The InstaDiag Breast pathway already consolidates all diagnostic examinations into a single day to establish a diagnosis.
-
Gold september: two new research programmes launched to tackle childhood cancers
Two of Gustave Roussy’s four new medical and scientific programmes are dedicated to childhood cancers. The first, DECRIPT, aims to improve understanding of the role played by genetics in the development of certain childhood cancers, as well as second cancers that may occur in adulthood. The second, INSPIRE, will draw on the knowledge and techniques already developed at the Institute to create organoids, with the aim of deciphering the mechanisms underlying metastasis and resistance to treatment.
-
Prof. Fabrice Barlesi reappointed at the head of Gustave Roussy, the leading cancer center in France and Europe
By order of Ms. Stéphanie Rist, Minister of Health, Families, Autonomy and Persons with Disabilities, dated 27 July 2026, Professor Fabrice Barlesi has been reappointed as Director General of Gustave Roussy, effective 1 August 2026. At the helm of the Institute for five more years, Prof. Barlesi will continue the transformations undertaken during his first term. This renewal reflects the confidence placed in the project led by the institution to accelerate progress in the fight against cancer, foster and support the development of innovations set to change the future of oncology, and strengthen the influence of one of the world's leading cancer centers.
