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List of research teams

Biology of Myeloid Cells and Cancer

  • Chaire Fondation Gustave Roussy
  • ERC - European Research Council
Thematic(s)
Immuno-oncology, Tumor microenvironment, Pediatric Oncology, Innovative Therapies
Attachment unit
U1356 - Research and Innovative Therapies in Pediatric and Adult Immuno-Oncology
Manager(s)
Florent Ginhoux
Institutional connection

Gustave Roussy, Inserm, Paris-Saclay University

Summary

Objectives and Challenges

The team is studying tumor-associated macrophages (TAMs), key players in the tumor microenvironment (TME), as well as other subpopulations of myeloid cells. Despite the success of immunotherapies targeting immune checkpoint inhibitors (ICIs), TAMs—which are heterogeneous and poorly understood—limit their effectiveness. Their diversity (embryonic or monocytic origin, duration of residence in the tumor) and their pro- or anti-tumor roles remain to be elucidated in order to develop targeted and personalized therapies.

Research Areas / Main Projects

  • Mapping of myeloid cells: Use of unique mouse models to trace the heterogeneity of myeloid cells (ontogeny, residence time).

  • Integration of human data: Multidimensional analysis (mRNA, proteins, epigenetics, spatial localization) of dynamic cohorts to identify new therapeutic targets.

  • 3D modeling: Study of macrophages in pediatric cancers using organoids/tumoroids derived from iPS cells, for personalized approaches (“patient avatar”).

Key findings, future directions, and impacts

  • Results: Discovery of the developmental origin of macrophages (3 distinct waves) and their adaptation to tissue niches, applied to the TME.

  • Future Directions: Identifying myeloid targets for new immunotherapies, taking into account the diversity of TAMs and their location within the tumor.

  • Impacts

    • Scientific: Advancement in the understanding of TAM heterogeneity. C

    • Clinical: Development of therapeutic strategies specifically targeting subpopulations of myeloid cells (reprogramming or elimination). 

    • Societal: Improvement of cancer treatments, particularly in pediatric cancer, through innovative and personalized approaches.

Team members

  • Florent GINHOUX - Team Leader

    Researcher / Scientific Director, Gustave Roussy Foundation

     

    ANAGNOSTOPOULOS G. 

    Postdoc, Gustave Roussy

     

    Méline Antunes 

    ITA / Technical Support, Gustave Roussy

     

    BAGATTIN Alessia 

    Postdoc, Gustave Roussy

     

    BERNIGOLE Flavie 

    ITA / Technical Support, Gustave Roussy

     

    BIED Mathilde 

    Ph.D. student

     

    Cloé Bourrelier 

    ITA / Technical Support, Gustave Roussy

     

    Clémence Cornuot 

    Ph.D. student

     

    Auriane COUTANSAIT 

    ITA / Technical Support, Gustave Roussy

     

    Carlos DE LA CALLE FABREGAT 

    Postdoc, Gustave Roussy

     

    DE SOUSA ROBERT Leslie 

    ITA / Technical Support, Gustave Roussy

     

    DOS SANTOS CARNEIRO, Mayra 

    ITA / Technical Support, Gustave Roussy

     

    DUNSMORE Garett 

    Postdoc, Gustave Roussy

     

    ELSHAER Farida 

    ITA / Technical Support, Gustave Roussy

     

    GARDET Margaux 

    Postdoc, Gustave Roussy

     

    Grégoire Gessain 

    Clinician / University Hospital, Gustave Roussy

     

    GONCALVES PESTANA DINIZ L.

    ITA / Technical Support, Gustave Roussy

     

    Raphaël Hartmann 

    Ph.D. Candidate

     

    HEYDARI OLYA Ariane 

    Postdoc, Gustave Roussy

     

    JOLY Paul 

    Ph.D. student

     

    KLOECKNER Benoit 

    Ph.D. student

     

    KONG Wan Ting 

    Ph.D. student

     

    LIU Pengyi 

    Ph.D. student

     

    LUSCAN Romain 

    Ph.D. student

     

    Lucie Madrange 

    ITA / Technical Support, Gustave Roussy

     

    Lucie MAISONNEUVE 

    Postdoc, Gustave Roussy

     

    MARTIN, Fanny 

    ITA / Technical Support, Gustave Roussy

     

    Véronique MINARD-COLIN 

    Clinician / University Hospital, Gustave Roussy

     

    Marco MOREIRA 

    Ph.D. Candidate

     

    Claudia PASQUALINI 

    Clinician / University Hospital Physician, Gustave Roussy

     

    Jeanne PICARD VALLAR 

    Ph.D. Student

     

    ROCHETTE Nicolas 

    ITA / Technical Support, Gustave Roussy

     

    Aymeric SILVIN 

    Researcher / Scientific Director, Gustave Roussy

     

    THEOBALD Hannah 

    Postdoc, Gustave Roussy

     

    TOUAZI Nabila 

    ITA / Technical Support, Gustave Roussy

     

    VILLAR LEAL Javiera Paz 

    Postdoc, Gustave Roussy

     

    YATIM Aline 

    Ph.D. student

     

    ZHANG Zijie 

    Postdoc, Gustave Roussy

     

    ZOUGGAR Safia 

    Administration / Administrative Support, Gustave Roussy

Contacts

Phone
Administrator: 01.42.11.37.73
Location: Gustave Roussy Institute