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List of research teams

Molecular Characterization of Breast and Gynecologic Cancers

Thematic(s)
Genetics / Genomics, Precision Medicine, Tumor Metabolism, Tumor microenvironment
Attachment unit
U981 - Molecular Predictors and New Targets in Oncology
Manager(s)
Fabrice André
Institutional connection

Gustave Roussy, Inserm, Paris-Saclay University

Summary

Prof. Fabrice André : Molecular characterization of Breast & Gynecologic cancers Team / Dr. Geraldine Gentric : Cancer Metabolism & Therapy Resistance Lab / Dr Clara Nahmias : Microtubules & Cancers Lab / Prof. Alexandra Leary: Novel therapies & predictive biomarkers in gynecologic cancers Lab

Objectives and Challenges

The “Molecular Characterization of Breast and Gynecologic Cancers” team ," led by Fabrice André, is dedicated to studying the molecular and intratumoral heterogeneity of breast and gynecological cancers in order to identify actionable biomarkers and the factors responsible for disease progression. The team investigates the genomic, epigenomic, and spatial determinants of tumor evolution and metastatic spread, focusing on the mechanisms underlying treatment resistance in advanced gynecologic cancers. 

Research Areas/Major Projects

The work of the group led by Fabrice André aims to refine patient stratification and enable the implementation of more effective, biomarker-guided therapeutic strategies for aggressive forms of the disease (metastatic breast cancer). 

Within the team, Geraldine Gentric leads the MetaboCare group, which studies the links between metabolic reprogramming and cancer cell plasticity in treatment resistance and disease recurrence. This research combines spatial metabolomics, functional profiling, and the use of patient-derived cellular models to understand the effects of anticancer treatments on the remodeling of tumor cells. One of the key objectives of this research is to identify metabolic vulnerabilities in residual tumor cells and to translate these analyses into therapeutic strategies for patients with treatment-resistant cancers. This research is part of the UNLOCK program at the IHU PRISM.

The group led by Alexandra Leary and Valeria Naim seeks to identify new therapies and predictive biomarkers in ovarian, uterine, and cervical cancers by targeting the response to DNA damage and the tumor microenvironment. This research combines translational science and clinical trials to evaluate new therapeutic strategies. 

The “Microtubules and Cancer” group, led by Clara Nahmias, studies microtubule-associated proteins as prognostic and predictive biomarkers for triple-negative breast cancer and high-grade serous ovarian cancer, based on molecular studies conducted on patient cohorts. Studies of microtubule interactions with cellular organelles aim to develop new targeted therapies for specific patient populations.

Team members

  • ANDRÉ Fabrice – Team Leader
    Professor of Universities and Hospital Practitioner, Gustave Roussy, Paris-Saclay University

     

    ACHUTTI-DUSO Bruno
    Hospital Practitioner, Gustave Roussy

     

    AMSEYAN Carine
    Other Status (including Apprentice), Gustave Roussy

     

    BARILLOT Noémie
    Other Status (including Apprentice), Gustave Roussy

     

    DAIDJ Ferroudja
    Other Status (including Apprentice), Gustave Roussy

     

    DIXON-DOUGLAS Julia
    Hospital Practitioner, Gustave Roussy

     

    FERNANDEZ MARTINEZ Aranzazu
    Hospital Practitioner, Gustave Roussy

     

    FERREIRA DO COUTO Karine
    Research Technician or Equivalent, Gustave Roussy

     

    GARBERIS Ingrid
    Other Status (including Apprentice), Gustave Roussy

     

    LACROIX-TRIKI Magalie
    Hospital Practitioner, Gustave Roussy

     

    MAZET Paul
    PhD Student, Paris-Saclay University

     

    MORAGON TERENCIO Santiago
    PhD Student, Inserm

     

    MOSELE Maria Fernanda
    PhD Student, Paris-Saclay University

     

    NURY Thomas
    Postdoctoral Researcher, Gustave Roussy

     

    PIC Isabelle
    Research Technician or Equivalent, Gustave Roussy

     

    SIREROL Marine
    Research Engineer or Equivalent, Gustave Roussy

     

    TRAN Thi Ngoc Diep
    Senior Research Engineer or Equivalent, Gustave Roussy

     

    VERRET Benjamin
    PhD Student, Paris-Saclay University

     

    WHITTUM Andrew
    Other Status (including Apprentice), Gustave Roussy

     

     

     

    GENTRIC Géraldine – Group Leader
    Research Scientist, Inserm

     

    AGUADO Aurore
    PhD Student, Gustave Roussy

     

    LUBY Angèle
    Senior Research Engineer or Equivalent, Gustave Roussy

     

    MORELLI Alessandra
    Postdoctoral Researcher, Gustave Roussy

     

     

     

    LEARY Alexandra – Co-Group Leader
    Professor of Universities and Hospital Practitioner, Gustave Roussy, Paris-Saclay University

     

    NAIM Valéria – Co-Group Leader
    Research Scientist, Inserm

     

    BLANC-DURAND Félix
    PhD Student, Paris-Saclay University

     

    BOINET Marie
    Research Engineer or Equivalent, Gustave Roussy

     

    GENESTIE Catherine
    Hospital Practitioner, Gustave Roussy

     

    GRAU-BEJAR Juan Francisco
    PhD Student, Paris-Saclay University

     

    LE FORMAL Audrey
    Research Technician or Equivalent, Gustave Roussy

     

    PELOSI Michele
    Senior Research Engineer or Equivalent, Gustave Roussy

     

    ROULEAU Etienne
    Hospital Practitioner, Gustave Roussy

     

    SOUEIDY Charbel
    Hospital Practitioner, Gustave Roussy

     

    YANIZ-GALENDE Elisa
    Postdoctoral Researcher, Gustave Roussy

     

     

     

    NAHMIAS Clara – Group Leader
    Research Director, CNRS

     

    LAW-POIS Maya
    Contract Research Engineer, Other Institution

     

    RODRIGUES-FERREIRA Sylvie
    Contract Researcher, Other Institution

     

    YVENOU Johan
    PhD Student, Paris-Saclay University

     

    ZOBOLI Samuele
    Research Technician or Equivalent, Gustave Roussy

Contacts

Location: Gustave Roussy Institute