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Molecular Characterization of Breast and Gynecologic Cancers
- Thematic(s)
- Genetics / Genomics, Precision Medicine, Tumor Metabolism, Tumor microenvironment
- Attachment unit
- U981 - Molecular Predictors and New Targets in Oncology
- Manager(s)
- Fabrice André
- Institutional connection
-
Gustave Roussy, Inserm, Paris-Saclay University
Summary
Objectives and Challenges
The “Molecular Characterization of Breast and Gynecologic Cancers” team ," led by Fabrice André, is dedicated to studying the molecular and intratumoral heterogeneity of breast and gynecological cancers in order to identify actionable biomarkers and the factors responsible for disease progression. The team investigates the genomic, epigenomic, and spatial determinants of tumor evolution and metastatic spread, focusing on the mechanisms underlying treatment resistance in advanced gynecologic cancers.
Research Areas/Major Projects
The work of the group led by Fabrice André aims to refine patient stratification and enable the implementation of more effective, biomarker-guided therapeutic strategies for aggressive forms of the disease (metastatic breast cancer).
Within the team, Geraldine Gentric leads the MetaboCare group, which studies the links between metabolic reprogramming and cancer cell plasticity in treatment resistance and disease recurrence. This research combines spatial metabolomics, functional profiling, and the use of patient-derived cellular models to understand the effects of anticancer treatments on the remodeling of tumor cells. One of the key objectives of this research is to identify metabolic vulnerabilities in residual tumor cells and to translate these analyses into therapeutic strategies for patients with treatment-resistant cancers. This research is part of the UNLOCK program at the IHU PRISM.
The group led by Alexandra Leary seeks to identify new therapies and predictive biomarkers in ovarian, uterine, and cervical cancers by targeting the response to DNA damage and the tumor microenvironment. This research combines translational science and clinical trials to evaluate new therapeutic strategies.
The “Microtubules and Cancer” group, led by Clara Nahmias, studies microtubule-associated proteins as prognostic and predictive biomarkers for triple-negative breast cancer and high-grade serous ovarian cancer, based on molecular studies conducted on patient cohorts. Studies of microtubule interactions with cellular organelles aim to develop new targeted therapies for specific patient populations.
Team members
-
ANDRÉ Fabrice - Team Leader
University Professors and Hospital Practitioners, Gustave Roussy, Paris-Saclay University
Bruno ACHUTTI-DUSO
Hospital Physician, Gustave Roussy
AGUADO Aurore
Ph.D. Student, Other
Carine AMSEYAN
Other status, including apprentice, Gustave Roussy
Noémie Barillot
Other status, including apprentice, Gustave Roussy
BAUDIN Eric
Hospital Physician, Gustave Roussy
Félix Blanc-Durand
Ph.D. student, Paris-Saclay University
BOINET, Marie
Design Engineer or equivalent, Gustave Roussy
DAIDJ Ferroudja
Other status, including apprentice, Gustave Roussy
Julia DIXON-DOUGLAS
Hospital Physician, Gustave Roussy
FERNADEZ MARTINEZ Aranzazu
Hospital Physician, Gustave Roussy
FERREIRA DO COUTO, Karine
Research Technician or Equivalent, Gustave Roussy
GARBERIS Ingrid
Other status, including apprentice, Gustave Roussy
Catherine Genestie
Hospital Physician, Gustave Roussy
Géraldine GENTRIC
Research Fellow and Equivalents, Inserm
GRAU-BEJAR Juan Francisco
Ph.D. Student, Paris-Saclay University
Magalie Lacroix-Triki
Hospital Physician, Gustave Roussy
LEARY Alexandra
University Professors and Hospital Practitioners, Gustave Roussy, Paris-Saclay University
Audrey LE FORMAL
Research Technician or Equivalent, Gustave Roussy
Angèle LUBY
Research Engineer or Equivalent, Gustave Roussy
MAZET Paul
Ph.D. Student, Paris-Saclay
Matthew MCKEON
Research Technician or equivalent, Gustave Roussy
MORAGON TERENCIO Santiago
Ph.D. student, Inserm
MORELLI Alessandra
Postdoctoral Fellow, Gustave Roussy
MOSELE Maria Fernanda
Ph.D. student, Paris-Saclay
NAHMIAS Clara
Research Director and Equivalents, CNRS
NAIM Valéria
Research Associate and Equivalents, Inserm
NURY Thomas
Postdoctoral Fellow, Gustave Roussy
PELOSI Michele
Research Engineer or equivalent, Gustave Roussy
PIC Isabelle
Research Technician or equivalent, Gustave Roussy
Sylvie RODRIGUES-FERREIRA
Design Engineer or equivalent, CNRS
ROULEAU Etienne
Hospital Physician, Gustave Roussy
SIREROL, Marine
Research Engineer or equivalent, Gustave Roussy
Charbel Soueidy
Hospital Physician, Gustave Roussy
TRAN Thi Ngoc Diep
Research Engineer or equivalent, Gustave Roussy
VERRET Benjamin
Ph.D. Candidate, Paris-Saclay
WHITTUM Andrew
Other status, including apprentice, Gustave Roussy
Elisa YANIZ-GALENDE
Postdoctoral researcher, Gustave Roussy
YVENOU Johan
Ph.D. student, Paris-Saclay
Key publications
Contacts
