Informations pratiques
Adresse

Gustave Roussy
114, rue Édouard-Vaillant
94805 Villejuif Cedex - France

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Tel : +33 (0)1 42 11 42 11

Urgences

Gustave Roussy n'assure que les urgences des patients pris en charge à l'Institut.
Urgences uniquement : +33 (0)1 42 11 50 00

GUSTAVE ROUSSY
1er centre de lutte contre le cancer en Europe, 3 000 professionnels mobilisés

Epitopes non-conventionnels et réponse immunitaire anti-cancéreuse

Responsable
Dr Sébastien Apcher

Contact :
Tél. : 33 (0)1 42 11 55 59
E-mail

Frise de présentation (bandeau): 
Epitopes non-conventionnels et réponse immunitaire anti-cancéreuse

Publications majeures

Nuclear processing of nascent transcripts determines synthesis of full-length proteins and antigenic peptides. Martins RP, Malbert-Colas L, Lista MJ, Daskalogianni C, Apcher S, Pla M, Findakly S, Blondel M, Fåhraeus R. Nucleic Acids Res. 2019 Apr 8;47(6):3086-3100.

A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation. Naret T, Bignon J, Bernadat G, Benchekroun M, Levaique H, Lenoir C, Dubois J, Pruvost A, Saller F, Borgel D, Manoury B, Leblais V, Darrigrand R, Apcher S, Brion JD, Schmitt E, Leroux FR, Alami M, Hamze A. Eur J Med Chem. 2018 Jan 1;143:473-490. doi: 10.1016/j.ejmech.2017.11.055.

Exosome-driven transfer of tumor-associated Pioneer Translation Products (TA-PTPs) for the MHC class I cross-presentation pathway. Duvallet E, Boulpicante M, Yamazaki T, Daskalogianni C, Prado Martins R, Baconnais S, Manoury B, Fahraeus R and Apcher S. Oncoimmunology, 2016 Jun 21;5(9):e1198865.

Melanoma miRNA trafficking controls tumour primary niche formation. Dror S, Sander L, Schwartz H, Sheinboim D, Barzilai A, Dishon Y, Apcher S, Golan T, Greenberger S, Barshack I, Malcov H, Zilberberg A, Levin L, Nessling M, Friedmann Y, Igras V, Barzilay O, Vaknine H, Brenner R, Zinger A, Schroeder A, Gonen P, Khaled M, Erez N, Hoheisel JD, Levy C. Nat Cell Biol. 2016 Sep;18(9):1006-17. doi: 10.1038/ncb3399.

The source of MHC class I presented peptides and its implications. Apcher S, Prado Martins R, Fåhraeus R. Curr Opin Immunol. 2016 Jun;40:117-22. doi: 10.1016/j.coi.2016.04.002. Epub 2016 Apr 19.

Pioneer translation products as an alternative source for MHC-I antigenic peptides. Apcher S, Daskalogianni C, Fåhraeus R. Mol. Immunol. 2015 May 12.

Translation of pre-spliced RNAs in the nuclear compartment generates peptides for the MHC class I pathway. Apcher S, Millot G, Daskalogianni C, Scherl A, Manoury B, Fåhraeus R. Proc Natl Acad Sci USA. 2013 Oct 29;110(44):17951-6.

The role of mRNA translation in direct MHC class I antigen presentation. Apcher S, Manoury B, Fåhraeus R. Curr. Opin. Immunol. 2012 Feb; 24(1):71-6.

Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation. Apcher S, Daskalogianni C, Lejeune F, Manoury B, Imhoos G, Heslop L, Fåhraeus  R. Proc Natl Acad Sci USA. 2011 Jul  12;108(28):11572-7.

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