Epidemiology of radiation

Epidemiology of radiation

This team is part of UMR 1018/CESP - Centre for research in epidemiology and population health

The team focuses its work on the epidemiology of the effects of ionizing radiation on health, as well as all aspects of quality of life of  long term survivors from childhood cancers

For several years, the team has been building and monitoring cohorts of subjects exposed to widely varying levels of ionizing radiation doses: FCCSS cohort (cohort of children treated for cancer before the year 2000), ANGIO cohort (cohort of children treated by radiotherapy for cutaneous hemangioma), VENUS (cohort of patients treated for thyroid cancer) and TRAVNUCL (cohort of workers from contracting companies in the French nuclear industry).

 The team is also studying the genetic and environmental risk factors for differentiated thyroid cancer, and has conducted case-control studies in French Polynesia, Cuba and Eastern France. Moreover, our team is the only research team studying the health consequences of atmospheric nuclear tests carried out by France between 1966 and 1974 in French Polynesia.

The main cohort managed by the team is the French Childhood Cancer Survivors Study (FCCSS), which to date includes 7670 subjects treated before the year 2000 for solid childhood cancer in 5 French Cancer Centers, and who have survived at least 5 years. Very detailed clinical and therapeutic information was collected for all children, and the doses of ionizing radiation received by all healthy organs of the body during their radiotherapy were estimated using specific software developed by the team.  The follow-up of the cohort is carried out through access to medical records, the sending of self-questionnaires, the setting up of long-term follow-up consultations, and access to data from the National Health Data System (SNDS). A biological bank, BIOF, is being established and currently includes more than 3,000 subjects, for whom saliva and/or blood samples have been taken. The objective of the FCCSS and BIOF is to study the risk factors of iatrogenic pathologies, cancerous or not, developed by survivors of childhood cancer, which are very numerous and serious. We are working in particular on the interaction between genetic factors and treatments, and seek to identify subjects at very high risk of iatrogenic pathologies due to a specific genetic susceptibility. We are beginning to address the global study of the quality of life of these former patients, in particular the psychological, sociological and economic consequences of the iatrogenic pathologies they develop.
The team is also involved in several European research programs also addressing risk factors for secondary cancers, and cardiac and cerebrovascular pathologies after childhood cancer.

Perspectives

Our main goal is to develop risk models of iatrogenic pathologies taking into account behavioral risk factors, treatments received, genetic factors and the interaction between these factors. We are thus participating in the development of precision cancer medicine that takes better account of the quality of life of cancer survivors.

Major publications

1. Role of radiotherapy and chemotherapy in the risk of leukemia after childhood cancer: An international pooled analysis. Allodji RS, Tucker MA, Hawkins MM, Le Deley MC, Veres C, Weathers R, Howell R, Winter D, Haddy N, Rubino C, Diallo I, Little MP, Morton LM, de Vathaire F. Int J Cancer. 2020 Oct 26. doi: 10.1002/ijc.33361. Online ahead of print. PMID: 33105035
    
2. Risk Factors of Subsequent Central Nervous System Tumors after Childhood and Adolescent Cancers: Findings from the French Childhood Cancer Survivor Study. Journy NMY, Zrafi WS, Bolle S, Fresneau B, Alapetite C, Allodji RS, Berchery D, Haddy N, Kobayashi I, Labbé M, Pacquement H, Pluchart C, Schwartz B, Souchard V, Thomas-Teinturier C, Veres C, Vu-Bezin G, Diallo I, de Vathaire F. Cancer Epidemiol Biomarkers Prev. 2021 Jan;30(1):133-141. doi: 10.1158/1055-9965.EPI-20-0735. Epub 2020 Oct 8. PMID: 33033142
    
3. Thyroid Doses to French Polynesians Resulting from Atmospheric Nuclear Weapons Tests: Estimates Based on Radiation Measurements and Population Lifestyle Data. Drozdovitch V, Bouville A, Taquet M, Gardon J, Xhaard C, Ren Y, Doyon F, de Vathaire F. Health Phys. 2021 Jan;120(1):34-55. doi: 10.1097/HP.0000000000001262. PMID: 33002966
    
4. Influence of growth hormone therapy on the occurrence of a second neoplasm in survivors of childhood cancer. Thomas-Teinturier C, Oliver-Petit I, Pacquement H, Fresneau B, Allodji RS, Veres C, Bolle S, Berchery D, Demoor-Goldschmidt C, Haddy N, Diallo I, de Vathaire F. Eur J Endocrinol. 2020 Oct;183(4):471-480. doi: 10.1530/EJE-20-0369. PMID: 32738133
    
5. Identifying clusters of health risk behaviors and their predictors in adult survivors of childhood cancer: A report from the French Childhood Cancer Survivor Study. Pinto S, Fresneau B, Hounsossou HC, Mayet A, Marchi J, Pein F, Journy N, Mansouri I, Drubay D, Letort V, Lemler S, Demoor-Goldschmidt C, Jackson A, Souchard V, Vu-Bezin G, Diallo I, Rubino C, Oberlin O, Haddy N, de Vathaire F, Dumas A, Allodji RS. Psychooncology. 2020 Oct;29(10):1595-1603. doi: 10.1002/pon.5470. Epub 2020 Aug 5. PMID: 32658375
    
6. Risk Factors for Small Adult Height in Childhood Cancer Survivors. Demoor-Goldschmidt C, Allodji RS, Journy N, Rubino C, Zrafi WS, Debiche G, Llanas D, Veres C, Thomas-Teinturier C, Pacquement H, Vu-Bezin G, Fresneau B, Berchery D, Bolle S, Diallo I, Haddy N, de Vathaire F.J Clin Oncol. 2020 Jun 1;38(16):1785-1796. doi: 10.1200/JCO.19.02361. Epub 2020 Mar 20. PMID: 32196392
    
7. Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup. Allodji RS, Hawkins MM, Bright CJ, Fidler-Benaoudia MM, Winter DL, Alessi D, Fresneau B, Journy N, Morsellino V, Bárdi E, Bautz A, Byrne J, Feijen ELA, Teepen JC, Vu-Bezin G, Rubino C, Garwicz S, Grabow D, Gudmundsdottir T, Guha J, Hau EM, Jankovic M, Kaatsch P, Kaiser M, Linge H, Muraca M, Llanas D, Veres C, Øfstaas H, Diallo I, Mansouri I, Ronckers CM, Skinner R, Terenziani M, Wesenberg F, Wiebe T, Sacerdote C, Jakab Z, Haupt R, Lähteenmäki P, Zaletel LZ, Kuehni CE, Winther JF, Michel G, Kremer LCM, Hjorth L, Haddy N, de Vathaire F, Reulen RC. Eur J Cancer. 2019 Aug;117:71-83. doi: 10.1016/j.ejca.2019.05.013. Epub 2019 Jun 28. PMID: 31260818
    
8. The role of irradiated heart and left ventricular volumes in heart failure occurrence after childhood cancer. Mansouri I, Allodji RS, Hill C, El-Fayech C, Pein F, Diallo S, Schwartz B, Vu-Bezin G, Veres C, Souchard V, Dumas A, Bolle S, Thomas-Teinturier C, Pacquement H, Munzer M, Bondiau PY, Berchery D, Fresneau B, Oberlin O, Diallo I, De Vathaire F, Haddy N. Eur J Heart Fail. 2019 Apr;21(4):509-518. doi: 10.1002/ejhf.1376. Epub 2018 Dec 27. PMID: 30592114
    
9. Risk of subsequent colorectal cancers after a solid tumor in childhood: Effects of radiation therapy and chemotherapy. Allodji RS, Haddy N, Vu-Bezin G, Dumas A, Fresneau B, Mansouri I, Demoor-Goldschmidt C, El-Fayech C, Pacquement H, Munzer M, Bondiau PY, Berchery D, Oberlin O, Rubino C, Diallo I, de Vathaire F. Pediatr Blood Cancer. 2019 Feb;66(2):e27495. doi: 10.1002/pbc.27495. Epub 2018 Oct 21. PMID: 30345604
    
10. Volume effects of radiotherapy on the risk of second primary cancers: A systematic review of clinical and epidemiological studies. Journy N, Mansouri I, Allodji RS, Demoor-Goldschmidt C, Ghazi D, Haddy N, Rubino C, Veres C, Zrafi WS, Rivera S, Diallo I, De Vathaire F. Radiother Oncol. 2019 Feb;131:150-159. doi: 10.1016/j.radonc.2018.09.017. Epub 2018 Oct 10. PMID: 30316563

Lab members

• Aba Naila Myriam
  Epidemiologist
• Allodji Rodrigue
  Biostatistician
• Bejarano Quisoboni Daniel    
  Epidemiologist
• Belhout Amel    
  Clinical research associate
• Boumaraf Amel    
  Clinical research associate
• Chappat Juliette    
  Biostatistician
• Chounta Stefania    
  Epidemiologist
• De Vathaire Florent    
  Epidemiologist
• Demoor Charlotte    
  Epidemiologist
• Ducos Claire    
  Epidemiologist
• Fresneau Brice    
  Epidemiologist
• Gbetchedji Alfred Arnaud    
  Epidemiologist
• Haddy Nadia    
  Epidemiologist
• Journy Neige    
  Epidemiologist
• Kobayashi Isao    
  Clinical research associate
• Labbe Martine    
  Clinical research associate
• Mansouri Imene    
  Epidemiologist
• Ngollo Marjolaine    
  Project manager
• Nys Julie    
  Project manager
• Rubino Carole    
  Epidemiologist
• Schwartz Boris    
  Biostatistician
• Souchard Vincent    
  Data manager
• Teinturier Cécile    
  Epidemiologist
• Terrier Francoise    
  Assistant manager
• Tran Thi-Chiên    
  Biostatistician
• Tran Thi Van Trinh    
  Epidemiologist
• Vu-Bezin Giao    
  Project manager
• Zidane Monia    
  Epidemiologist