Epidemiology of radiation, clinical epidemiology of cancer and survival

Group leader
Dr Florent de Vathaire

Contact
+ 33 (0)1 42 11 54 57

Bâtiment de médecine moléculaire, Level 0

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Epidemiology of radiation, clinical epidemiology of cancer and survival

Epidemiology of radiation, clinical epidemiology of cancer
and survival

This team is part of UMR 1018/CESP - Centre for research in epidemiology and population health

The team focuses on the epidemiology of the effects of ionizing radiation on health, as well as the long-term fate of patients treated for cancer.

The team focuses on the epidemiology of cancers, and more particularly on the epidemiology of the effects of ionizing radiation, the long-term iatrogenic effects of cancer treatments and the outcomes of patients treated for cancer or a tumor. The team also integrates developments in molecular epidemiology.

The main cohort of the team is the French Childhood Cancer Survivors Study (FCCSS), a multicentric national cohort of subjects treated before 2000 for a solid childhood cancer or lymphoma and who have survived at least 5 years. The objective of the FCCSS is to investigate the overall long-term outcomes of children and adolescents treated for cancer.

More precisely, the aims of the FCCSS study are to:

  • Identify and quantify the long-term effects of treatment,
  • Identify and quantify the risk factors associated with the long-term effects, in order to minimize the risks associated with treatments,
  • Identify individual genetic susceptibility to long-term effects,
  • Analyse the impact of cancer and its treatments on patients’ quality of life, education, employment, family life…

Very detailed clinical and therapeutic information was collected for all children, and the doses of ionizing radiation received by all the healthy organs of the body during their radiotherapy were estimated using specific software developed in the team. Other sources of information include: self-questionnaire, data of the National Health Insurance System (SNDS) and long-term follow-up consultations. BIOF is the biological bank, consisting of saliva and blood samples. The objective of BIOF is to study the genetic factors that could raise the risk of developing iatrogenic effects because of an increased susceptibility to anticancer treatments. For more information: http://fccss.fr

For several years, the team has also been developing and following cohorts of subjects exposed to highly variable levels of ionizing radiation: ANGIO cohort (cohort of children treated by radiotherapy for hemangioma), TOMENF cohort (cohort of children exposed to scanner examinations), VENUS (cohort of patients treated for thyroid cancer), SURVSEIN (cohort of women treated for breast cancer), TRAVNUCL (cohort of workers from contracting companies in the French nuclear industry). The team is also studying genetic and environmental risk factors for differentiated thyroid cancer, and has carried out case-control studies in French Polynesia, Cuba and Eastern France for this purpose.

The team is also involved in several European research programs that also focus on the risk factors for secondary cancers, and cardiac and cerebrovascular pathologies after childhood cancer.

Perspectives

The main objective of the team's work is to develop models and tools for predicting radiation-related iatrogenic risks, taking into account clinical, therapeutic, biological and genetic data.

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