Exploration and therapeutic modulation of host-tumor interactions in Head and Neck carcinomas

Group leaders
Dr Pierre Busson - Email
Pr Karim Benihoud - Email
Tel. : +33 (0)1 42 11 45 83


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Exploration and therapeutic modulation of host-tumor interactions in Head and Neck carcinomas

Major publications

  • Makowska A, Franzen S, Braunschweig T, Denecke B, Shen L, Baloche V, Busson P, Kontny U. (2019) Interferon beta increases NK cell cytotoxicity against tumor cells in patients with nasopharyngeal carcinoma via tumor necrosis factor apoptosis-inducing ligand. Cancer Immunol. Immunother. 68:1317-1329. PMID: 31312900.
  • Messick TE, Smith GR, Soldan SS, McDonnell ME, Deakyne JS, Malecka KA, Tolvinski L, van den Heuvel APJ, Gu BW, Cassel JA, Tran DH, Wassermann BR, Zhang Y, Velvadapu V, Zartler ER, Busson P, Reitz AB, Lieberman PM. (2019) Structure-based design of small-molecule inhibitors of EBNA1 DNA binding blocks Epstein-Barr virus latent infection and tumor growth. Sci Transl Med. 11: eaau5612.
  • Mikulandra, M., Kobescak, A., Verillaud, B., Busson, P. and Matijevic Glavan, T. (2019) Radio-sensitization of head and neck cancer cells by a combination of poly(I:C) and cisplatin through downregulation of survivin and c-IAP2. Cellular oncology 42: 29-40.
  • Anchim A, Raddi N, Zig L, Perrieau P, Le Goffic R, Ryffel B, Benihoud K. (2018) Humoral Responses Elicited by Adenovirus Displaying Epitopes Are Induced Independently of the Infection Process and Shaped by the Toll-Like Receptor/MyD88 Pathway. Front Immunol. 9:124. PMID: 29459860.
  • Lhuillier, C., Barjon, C., Baloche, V., Niki, T., Gelin, A., Mustapha, R., Claer, L., Hoos, S., Chiba, Y., Ueno, M., Hirashima, M., Wei, M., Morales, O., Raynal, B., Delhem, N., Dellis, O. and Busson, P. (2018) Characterization of neutralizing antibodies reacting with the 213-224 amino-acid segment of human galectin-9. PLoS One, 13: e0202512.
  • Bressy C, Majhen D, Raddi N, Jdey W, Cornilleau G, Zig L, Guirouilh-Barbat J, Lopez BS, Bawa O, Opolon P, Grellier E, Benihoud K. (2017) Combined therapy of colon carcinomas with an oncolytic adenovirus and valproic acid. Oncotarget. 8:97344-97360. PMID: 29228615.
  • Veyrat M., Durand S., Classe M., Matijevic-Glavan T., Oker N., Kapetanakis N. I., Jiang X., Gelin A., Herman P., Casiraghi O., Zagzag D., Enot D., Busson P., Vérillaud B. (2016) Stimulation of the toll-like receptor 3 promotes metabolic reprogramming in head and neck carcinoma cells. Oncotarget 13: 82580-82593.
  • Raddi N, Vigant F, Wagner-Ballon O, Giraudier S, Custers J, Hemmi S, Benihoud K. (2016) Pseudotyping Serotype 5 Adenovirus with the Fiber from Other Serotypes Uncovers a Key Role of the Fiber Protein in Adenovirus 5-Induced Thrombocytopenia. Hum Gene Ther. 27:193-201. PMID: 26757054.
  • Lhuillier, C., Barjon, C., Niki, T., Gelin, A., Praz, F., Morales, O., Souquere, S., Hirashima, M., Wei, M., Dellis, O., Busson, P. (2015) Impact of Exogenous Galectin-9 on Human T Cells: Contribution of the T-cell receptor complex to antigen-independent activation but not to apoptosis induction. Journal of Biological Chemistry 290, 16797-16811.
  • Ragot T, Provost C, Prignon A, Cohen R, Lepoivre M, Lausson S. (2015) Apoptosis induction by combination of drugs or a conjugated molecule associating non-steroidal anti-inflammatory and nitric oxide donor effects in medullary thyroid cancer models: implication of the tumor suppressor p73. Thyroid Res.14; 8:13. PMID: 26273323.
  • Lucas T, Benihoud K, Vigant F, Schmidt CQ, Wortmann A, Bachem MG, Simmet T, Kochanek S. (2015) Hexon modification to improve the activity of oncolytic adenovirus vectors against neoplastic and stromal cells in pancreatic cancer. PLoS One, 10(2):e0117254. doi: 10.1371/journal.pone.0117254. eCollection 2015.
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