Double-strand break repair, Replication stress and Genome Integrity

Group leaders

Gérard Mazon
E-mail
Eric Le Cam
E-mail

Bâtiment de médecine moléculaire,
Niveau 2, Pièce 269

Frise Banner: 
Double-strand break repair, Replication stress and Genome Integrity

Major publications

1: Tavares EM, Wright WD, Heyer WD, Le Cam E, Dupaigne P. In vitro role of Rad54 in Rad51-ssDNA filament-dependent homology search and synaptic complexes formation. Nat Commun. 2019 Sep 6;10(1):4058. doi: 10.1038/s41467-019-12082-z.

2 : Bernal M, Yang X, Lisby M, Mazón G. The FANCM family Mph1 helicase localizes to the mitochondria and contributes to mtDNA stability. DNA Repair (Amst). 2019 Oct;82:102684. doi: 10.1016/j.dnarep.2019.102684. Epub 2019 Aug 9.

3: Talhaoui I, Bernal M, Mullen JR, Dorison H, Palancade B, Brill SJ, Mazón G. Slx5-Slx8 ubiquitin ligase targets active pools of the Yen1 nuclease to limitcrossover formation. Nat Commun. 2018 Nov 27;9(1):5016. doi:10.1038/s41467-018-07364-x.

4: Nemoz C, Ropars V, Frit P, Gontier A, Drevet P, Yu J, Guerois R, Pitois A, Comte A, Delteil C, Barboule N, Legrand P, Baconnais S, Yin Y, Tadi S, Barbet-Massin E, Berger I, Le Cam E, Modesti M, Rothenberg E, Calsou P, Charbonnier JB. XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining. Nat Struct Mol Biol. 2018 Oct;25(10):971-980. doi: 10.1038/s41594-018-0133-6.

5: Ma E, Dupaigne P, Maloisel L, Guerois R, Le Cam E, Coïc E. Rad52-Rad51 association is essential to protect Rad51 filaments against Srs2, but facultative for filament formation. Elife. 2018 Jul 9;7. pii: e32744. doi: 10.7554/eLife.32744.

6: Dupaigne P, Tavares EM, Piétrement O, Le Cam E. Recombinases and Related Proteins in the Context of Homologous Recombination Analyzed by Molecular Microscopy. Methods Mol Biol. 2018;1805:251-270. doi: 10.1007/978-1-4939-8556-2_13.

7: Eissler CL, Mazón G, Powers BL, Savinov SN, Symington LS, Hall MC. The Cdk/cDc14 module controls activation of the Yen1 holliday junction resolvase to promote genome stability. Mol Cell. 2014 Apr 10;54(1):80-93. doi: 10.1016/j.molcel.2014.02.012. Epub 2014 Mar 13.

8: Esta A, Ma E, Dupaigne P, Maloisel L, Guerois R, Le Cam E, Veaute X, Coïc E. Rad52 sumoylation prevents the toxicity of unproductive Rad51 filaments independently of the anti-recombinase Srs2. PLoS Genet. 2013;9(10):e1003833. doi: 10.1371/journal.pgen.1003833.

9: Mazón G, Symington LS. Mph1 and Mus81-Mms4 prevent aberrant processing of mitotic recombination intermediates. Mol Cell. 2013 Oct 10;52(1):63-74. doi: 10.1016/j.molcel.2013.09.007.

10: Mazón G, Lam AF, Ho CK, Kupiec M, Symington LS. The Rad1-Rad10 nuclease promotes chromosome translocations between dispersed repeats. Nat Struct Mol Biol. 2012 Sep;19(9):964-71. doi: 10.1038/nsmb.2359. Epub 2012 Aug 12.

Catégorie de la page: