Genetic and modelling of childhood leukaemia

Group leader
Prof. Thomas Mercher
+33 (0) 01 42 11 44 83

Administrative assistant
Paule Zanardo
+33 (0) 01 42 11 42 33
Fax: +33 (0)1 42 11 52 40

Pavillon de recherche 2, Level 3, Room 342

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Genetic and modelling of childhood leukaemia

Recent publications

  • Couronné L et al. STAT3 mutations identified in human hematological neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model. 
    Haematologica. 2013 Jul 19. PubMed PMID: 23872306.
  • Bluteau O et al. Developmental changes in human megakaryopoiesis. 
    J Thromb Haemost. 2013 Jun 19. doi: 10.1111/jth.12326. PubMed PMID: 23782903.
  • Malinge S et al. Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes. 
    Blood. 2013 Oct 3;122(14):e33-43. 
  • Bouchekioua A et al. JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma.  
    Leukemia. 2013 May 21. doi: 10.1038/leu.2013.157. PubMed PMID: 23689514.
  • Malinge S et al. Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling.  
    Blood. 2013 Jan 18. PMID: 23335373. 
    Comments: Maillard I, Blood. 2013 Mar 28;121(13):2376-7. PubMed PMID: 23538229.
  • Thiollier C, et al. Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models.
    J Exp Med. 2012 Oct 22;209(11):2017-31. doi: 10.1084/jem.20121343.
  • Wen Q et al. Identification of Regulators of Polyploidization Presents  Therapeutic Targets for Treatment of AMKL. 
    Cell. 2012 Aug 3;150(3):575-89. PubMed PMID: 22863010.
  • Malinge S et al. Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome. 
    J Clin Invest. 2012 Mar 1;122(3):948-62. 
  • Quivoron C et al. TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis. 
    Cancer Cell. 2011 Jun 29. [Epub ahead of print] PubMed PMID: 21723201.
  • Cornejo MG et al. Crosstalk between Notch and AKT signaling during murine megakaryocyte lineage  specification. 
    Blood. 2011 Jun 7. [Epub ahead of print] PubMed PMID: 21653327.
  • Mercher T et al. OTT-MAL activates RBPJ transcription and induces acute megakaryoblastic leukemia in a knock-in mouse model. 
    J Clin Invest. 2009 Apr;119(4):852-64. doi: 10.1172/JCI35901.
    Cornejo MG et al. Constitutive JAK3     activation induces lymphoproliferative syndromes in murine bone marrow transplant models.
    Blood. 2009 Mar 19;113(12):2746-54.
  • Mercher T et al. Notch signaling specifies megakaryocyte development from hematopoietic stem cells.
    Cell Stem Cell. 2008 Sep 11;3(3):314-26.

Full list of publication (download PDF below): 

PDF iconlist_of_publications_mercher.pdf

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