Biology of pediatric leukaemia

Recent publications

• Fagnan A, Aid Z, Baille M, Drakul A, Robert E, Lopez CK, Thirant C, Lecluse Y, Rivière J, Ignacimouttou C, Salmoiraghi S, Anguita E, Naimo A, Marzac C, Pflumio F, Malinge S, Wichmann C, Huang Y, Lobry C, Chaumeil J, Soler E, Bourquin JP, Nerlov C, Bernard OA, Schwaller J, Mercher T. The ETO2 transcriptional co-factor maintains acute leukemia by driving a MYB/EP300-dependent stemness program.
  Hemasphere. 2024. in press
• Henry E, Picou F, Barroca V, Dechamps N, Sobrino S, Six E, Gobeaux C, Auberger P, Hérault O, Pflumio F, Arcangeli ML. The Antioxidant TEMPOL Protects Human Hematopoietic Stem Cells From Culture-Mediated Loss of Functions.
  Stem Cells Transl Med. 2023. 2023 Oct 5;12(10):676-688. PMID: 37616262
• Aid Z, Robert E, Lopez CK, Bourgoin M, Boudia F, Le Mene M, Riviere J, Baille M, Benbarche S, Renou L, Fagnan A, Thirant C, Federici L, Touchard L, Lecluse Y, Jetten A, Geoerger B, Lapillonne H, Solary E, Gaudry M, Meshinchi S, Pflumio F, Auberger P, Lobry C, Petit A, Jacquel A, Mercher T. High caspase 3 and vulnerability to dual BCL2 family inhibition define ETO2::GLIS2 pediatric leukemia.
  Leukemia. 2023 Mar;37(3):571-579. doi: 10.1038/s41375-022-01800-0. PMID: 36585521
• Barroca V., Henry E., Dechamps N., Renou L., Chaintreuil P., Kulkarni R., Devanand S., Jacquel A., Robert G., Auberger P., Pflumio F. and Arcangeli ML. REDD1 Is a Gatekeeper of Murine Hematopoietic Stem Cell Functions during Stress Responses.
  Leukemia 2022. Aug;36(8):2140-2143. PMID: 35641638
• Arkoun B, Robert E, Boudia F, Mazzi S, Dufour V, Siret A, Mammasse Y, Aid Z, Vieira M, Imanci A, Aglave M, Cambot M, Petermann R, Souquere S, Rameau P, Catelain C, Diot R, Tachdjian G, Hermine O, Droin N, Debili N, Plo I, Malinge S, Soler E, Raslova H, Mercher T*, Vainchenker W*. Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model.
  *Co-last & corresponding     
  J Clin Invest. 2022 May 19:e156290. PMID: 35587378.
• Babin L, Darchen A, Robert E, Aid Z, Borry R, Soudais C, Piganeau M,vDe Cian A4, Giovannangeli C, Bawa O, Rigaud C, Scoazec JY, Couronne L, Veleanu L, Cieslak A, Asnafi V, Sibon D, Lamant L, Meggetto F, Mercher T*, Brunet E*. De novo generation of the NPM-ALK fusion recapitulates the pleiotropic phenotypes of ALK+ ALCL pathogenesis and reveals the ROR2 receptor as target for tumor cells. *Co-corresponding
  Molecular Cancer. 2022 Mar 4;21(1):65. PMID: 35246138
• Benbarche S, Lopez CK, Salataj E, Aid Z, Thirant C, Laiguillon MC, Lecourt S, Belloucif Y, Vaganay C, Antonini M, Hu J, Pardieu B, Petit A, Puissant A, Chaumeil J, Mercher T*, Lobry C*. Screening of ETO2-GLIS2–induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia. *Co-last & corresponding
  Science Advances. 2022 Feb 11;8(6):eabg9455. PMID: 35138899
• Henry E., Barroca V., Lopez CK., Aurrand-Lions M., Lewandowski D., Mercher T. and Arcangeli ML. JAM-C/Jam-C Expression Is Primarily Expressed in Mouse Hematopoietic Stem Cells.
  Hemasphere 2021. Jun 12;5(7):e594. PMID: 34131634
• Fagnan A, Otzen Bagger F, Piqué-Borràs MR, Ignacimouttou C, Caulier A, Lopez CK, Robert E, Uzan B, Gelsi-Boyer V, Aid Z, Thirant C, Moll U, Tauchmann S, Kurtovic-Kozaric A, Maciejewski J, Dierks C,  Spinelli O, Salmoiraghi S, Pabst T, Shimoda K, Deleuze V, Lapillonne H, Sweeney C, De Mas V, Leite B, Kadri Z, Malinge S, de Botton S, Micol JB, Kile B, Carmichael CL, Iacobucci I, Mullighan C, Caroll M, Valent P, Bernard OA, Delabesse E, Vyas P, Birnbaum D, Anguita E, Garçon L, Soler E, Schwaller J, Mercher T. Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers.
  Blood. 2020;136(6):698-714. PMID: 32350520
  Comment:
  Strouboulis J. Erythroleukemia: all roads lead to GATA1?. Blood. 2020;136(6):648-649. doi:10.1182/blood.2020006107
• Henry E., Souissi-Sahraoui I., Deynoux M., Lefèvre A., Barroca V., Campalans A., Ménard V., Calvo J., Pflumio F. and Arcangeli ML. Human Hematopoietic Stem/Progenitor Cells Display Reactive Oxygen Species-Dependent Long-Term Hematopoietic Defects after Exposure to Low Doses of Ionizing Radiations.
  Haematologica 2020. Aug;105(8):2044-2055. PMID: 31780635
  Editorial:
  Yamashita M & Suda T Low-dose of ionizing radiations leave scars on human hematopoietic stem and progenitor cells: the role of reactive oxygen species. Haematologica 2021 106(1):320-322.PMID: 33386716  
• Bertuccio SN*, Boudia F*, Cambot M 2,4 *, Lopez CK, Lordier L, Donada A, Robert E, Thirant C, Aid Z, Serravalle S, Astolfi A, Indio V, Locatelli F, Pession A, Vainchenker W, Masetti R, Raslova H, Mercher T. The pediatric acute leukemia fusion oncogene ETO2-GLIS2 increases self-renewal and alters differentiation in a human induced pluripotent stem cells-derived model.
  Hemasphere. 2020 Jan 22;4(1):e319. PubMed PMID: 32072139
• Lopez CK, Noguera E, Stavropoulou V, Robert E, Aid Z, Ballerini P, Bilhou-Nabera C, Lapillonne C, Boudia F, Thirant C, Fagnan A, Arcangeli ML, Kinston SJ, Diop M, Job B, Lecluse Y, Brunet E, Babin L, Villeval JL, Delabesse E, Peters AHFM, Vainchenker W, Gaudry M, Masetti R, Locatelli F, Malinge S, Nerlov C, Droin N, Lobry C, Godin I, Bernard OA, Göttgens B, Petit A, Pflumio F, Schwaller J, Mercher T. Ontogenic changes in hematopoietic hierarchy determine pediatric specificity and disease phenotype in fusion oncogene-driven myeloid leukemia
  Cancer Discovery. 2019 Oct 29. PubMed PMID: 31662298.
  Comment:
  Cancer Discovery. 2017. Cruz Hernandez D & Vyas P. Oncogenic Drivers and Development. Cancer Discov. 2019;9(12):1653-1655. doi:10.1158/2159-8290.CD-19-1082
• Thirant C, Ignacimouttou C, Lopez CK, Diop MB, Le Mouël L, Thiollier C, Siret A, Dessen P, Aid Z, Rivière J, Rameau P, Lefebvre C, Khaled M, Leverger G, Ballerini P, Petit A, Raslova H, Carmichael CL, Kile BT, Soler E, Crispino JD, Wichmann C, Pflumio F, Schwaller J, Vainchenker W, Lobry C, Droin N, Bernard OA, Malinge S, Mercher T. ETO2-GLIS2 hijacks transcriptional complexes to drive cellular identity and self-renewal in pediatric acute megakaryoblastic leukemia.
  Cancer Cell. 2017. Mar 13;31(3):452-465.   
  Comments:
  Cancer Cell. 2017. ETO2-GLIS2: A Chimeric Transcription Factor Drives Leukemogenesis through a Neomorphic Transcription Network. Wheat JC, Steidl U.
  Cancer Discovery. 2017. ETO2–GLIS2 Drives the Transcriptional Program Underlying AMKL. DOI: 10.1158/2159-8290
• Thiollier C, Lopez CK, Gerby B, Ignacimouttou C, Poglio S, Duffourd Y, Guégan J, Rivera-Munoz P, Bluteau O, Mabialah V, Diop M, Wen Q, Petit A, Bauchet AL, Reinhardt D, Bornhauser B, Gautheret D, Lecluse Y, Landman-Parker J, Radford I, Vainchenker W, Dastugue N, de Botton S, Dessen P, Bourquin JP, Crispino JD, Ballerini P, Bernard OA, Pflumio F, Mercher T. Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models.
  J Exp Med. 2012 Oct 22;209(11):2017-31. doi: 10.1084/jem.20121343.
• Cornejo MG, Mabialah V, Sykes SM, Khandan T, Lo Celso C, Lopez C, Rivera-Muñoz P, Rameau P, Tothova Z, Aster JC, Depinho RA, Scadden DT, Gilliland DG, Mercher T. Crosstalk between Notch and AKT signaling during murine megakaryocyte lineage specification.
  Blood. 2011 Jun 7. [Epub ahead of print] PubMed PMID: 21653327.
• Mercher T, Raffel GD, Moore SA, Cornejo MG, Baudry-Bluteau D, Cagnard N, Jesneck JL, Pikman Y, Cullen DE, Williams IR, Akashi K, Shigematsu H, Bourquin JP, Giovannini M, Vainchenker W, Levine RL, Lee BH, Bernard OA, Gilliland DG. OTT-MAL activates RBPJ transcription and induces acute megakaryoblastic leukemia in a knock-in mouse model.
  J Clin Invest. 2009 Apr;119(4):852-64. doi: 10.1172/JCI35901.
• Cornejo MG, Kharas MG, Werneck MB, Le Bras S, Moore SA, Ball B, Beylot-Barry M, Rodig SJ, Aster JC, Lee BH, Cantor H, Merlio JP, Gilliland DG, Mercher T. Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplant models.
  Blood. 2009 Mar 19;113(12):2746-54.
• Mercher T, Cornejo MG, Sears C, Kindler T, Moore SA, Maillard I, Pear WS, Aster JC, Gilliland DG. Notch signaling specifies megakaryocyte development from hematopoietic stem cells.
  Cell Stem Cell. 2008 Sep 11;3(3):314-26.
• Mercher, T., Coniat, M.B., Monni, R., Mauchauffe, M., Khac, F.N., Gressin, L., Mugneret, F., Leblanc, T., Dastugue, N., Berger, R. and Bernard, O.A. (2001) Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia.
  Proc Natl Acad Sci USA, 98, 5776-5779.

Patent

Title: Methods for the treatment of anaplastic large cell lymphoma
Reference: BIO21072 BRUNET / MC/BTL
Date of submission: April 9th 2021
Status: co-inventor