Informations pratiques
Adresse

Gustave Roussy
114, rue Édouard-Vaillant
94805 Villejuif Cedex - France

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Tel : +33 (0)1 42 11 42 11

Urgences

Gustave Roussy n'assure que les urgences des patients pris en charge à l'Institut.
Urgences uniquement : +33 (0)1 42 11 50 00

GUSTAVE ROUSSY
1er centre de lutte contre le cancer en Europe, 3 000 professionnels mobilisés

Biologie des leucémies de l’enfant

Responsable
Dr Thomas Mercher
Tel : + 33 (0)1 42 11 44 83
E-mail

Secrétariat
Paule Zanardo
Tel : 01 42 11 42 33
Fax : 01 42 11 52 40
E-mail

Pavillon de recherche 2, Niveau 3
Pièce 342

Frise de présentation (bandeau): 
Biologie des leucémies de l’enfant

Publications récentes

  • Fagnan A, Otzen Bagger F, Piqué-Borràs MR, Ignacimouttou C, Caulier A, Lopez CK, Robert E, Uzan B, Gelsi-Boyer V, Aid Z, Thirant C, Moll U, Tauchmann S, Kurtovic-Kozaric A, Maciejewski J, Dierks C,  Spinelli O, Salmoiraghi S, Pabst T, Shimoda K, Deleuze V, Lapillonne H, Sweeney C, De Mas V, Leite B, Kadri Z, Malinge S, de Botton S, Micol JB, Kile B, Carmichael CL, Iacobucci I, Mullighan C, Caroll M, Valent P, Bernard OA, Delabesse E, Vyas P, Birnbaum D, Anguita E, Garçon L, Soler E, Schwaller J, Mercher T. Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers.
    Blood. 2020;136(6):698-714. PMID: 32350520
    Comment:
    Strouboulis J. Erythroleukemia: all roads lead to GATA1?. Blood. 2020;136(6):648-649. doi:10.1182/blood.2020006107
  • Leonards K, Almosailleakh M, Tauchmann S, Bagger F, Thirant C, Juge S, Bock T, Mereau H, Bezerra M, Tzankov A, Ivanek R, Losson R, Peters A, Mercher T, Schwaller J. Inactivation of the nuclear interacting SET domain protein 1 impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.
    Nat Commun. 2020 Jun 12;11(1):2807. PMID: 32533074
    Dossin F, Jan J. Zylicz JJ, Pinheiro I, Roensch J, Collombet S, Le Saux A, Chelmicki T, Kapoor V, Zhan Y, Dingli F, Loew D, Mercher T, Dekker J, Heard E. SPEN integrates transcriptional and epigenetic control of X-inactivation.
    Nature. 2020 Feb;578(7795):455-460. PubMed PMID: 32025035
  • Bertuccio SN*, Boudia F*, Cambot M 2,4 *, Lopez CK, Lordier L, Donada A, Robert E, Thirant C, Aid Z, Serravalle S, Astolfi A, Indio V, Locatelli F, Pession A, Vainchenker W, Masetti R, Raslova H, Mercher T. The pediatric acute leukemia fusion oncogene ETO2-GLIS2 increases self-renewal and alters differentiation in a human induced pluripotent stem cells-derived model.
    Hemasphere. 2020 Jan 22;4(1):e319. PubMed PMID: 32072139
  • Lopez CK, Noguera E, Stavropoulou V, Robert E, Aid Z, Ballerini P, Bilhou-Nabera C, Lapillonne C, Boudia F, Thirant C, Fagnan A, Arcangeli ML, Kinston SJ, Diop M, Job B, Lecluse Y, Brunet E, Babin L, Villeval JL, Delabesse E, Peters AHFM, Vainchenker W, Gaudry M, Masetti R, Locatelli F, Malinge S, Nerlov C, Droin N, Lobry C, Godin I, Bernard OA, Göttgens B, Petit A, Pflumio F, Schwaller J, Mercher T. Ontogenic changes in hematopoietic hierarchy determine pediatric specificity and disease phenotype in fusion oncogene-driven myeloid leukemia
    Cancer Discovery. 2019 Oct 29. PubMed PMID: 31662298.
    Comment: 
    Cancer Discovery. 2017. Cruz Hernandez D & Vyas P. Oncogenic Drivers and Development. Cancer Discov. 2019;9(12):1653-1655. doi:10.1158/2159-8290.CD-19-1082
  • Rivera-Munoz P, Laurent AP, Siret A, Lopez CK, Ignacimouttou C, Cornejo MG, Bawa O, Rameau P, Bernard OA, Dessen P, Gilliland GD, Mercher T*, Malinge S*. Partial trisomy 21 contributes to T-cell malignancies induced by JAK3-activating mutations in murine models. *Corresponding author.
    Blood Adv. 2018 Jul 10;2(13):1616-1627. PubMed PMID: 29986854
  • Teyssier AC, Lapillonne H, Pasquet M, Ballerini P, Baruchel A, Ducassou S, Fenneteau O, Petit A, Cuccuini W, Ragu C, Preudhomme C, Mercher T, Sirvent N, Leverger G. Acute megakaryoblastic leukemia (excluding Down syndrome) remains an acute myeloid subgroup with inferior outcome in the French ELAM02 trial.
    Pediatr Hematol Oncol. 2017 Nov;34(8):425-427. PubMed PMID: 29303660.
  • Lopez CK, Malinge S, Gaudry M, Bernard OA, Mercher T. Pediatric Acute Megakaryoblastic Leukemia: Multitasking Fusion Proteins and Oncogenic Cooperations.
    Trends Cancer. 2017 Sep;3(9):631-642. Review. PubMed PMID: 28867167.
  • Thirant C, Ignacimouttou C, Lopez CK, Diop MB, Le Mouël L, Thiollier C, Siret A, Dessen P, Aid Z, Rivière J, Rameau P, Lefebvre C, Khaled M, Leverger G, Ballerini P, Petit A, Raslova H, Carmichael CL, Kile BT, Soler E, Crispino JD, Wichmann C, Pflumio F, Schwaller J, Vainchenker W, Lobry C, Droin N, Bernard OA, Malinge S, Mercher T. ETO2-GLIS2 hijacks transcriptional complexes to drive cellular identity and self-renewal in pediatric acute megakaryoblastic leukemia. 
    Cancer Cell. 2017. Mar 13;31(3):452-465.
    Comments: 
    -Cancer Cell. 2017. ETO2-GLIS2: A Chimeric Transcription Factor Drives Leukemogenesis through a Neomorphic Transcription Network. Wheat JC, Steidl U.
    -Cancer Discovery. 2017. ETO2–GLIS2 Drives the Transcriptional Program Underlying AMKL. DOI: 10.1158/2159-8290
  • Thiollier C, Lopez CK, Gerby B, Ignacimouttou C, Poglio S, Duffourd Y, Guégan J, Rivera-Munoz P, Bluteau O, Mabialah V, Diop M, Wen Q, Petit A, Bauchet AL, Reinhardt D, Bornhauser B, Gautheret D, Lecluse Y, Landman-Parker J, Radford I, Vainchenker W, Dastugue N, de Botton S, Dessen P, Bourquin JP, Crispino JD, Ballerini P, Bernard OA, Pflumio F, Mercher T. Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models.
    J Exp Med. 2012 Oct 22;209(11):2017-31. doi: 10.1084/jem.20121343.
  • Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur  R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Goldberg L, Birger Y, Izraeli S, Gamis AS, Smith FO, Woods WG, Taub J, Scherer CA, Bradner JE, Goh BC,  Mercher T, Carpenter AE, Gould RJ, Clemons PA, Carr SA, Root DE, Schreiber SL, Stern AM, Crispino JD. Identification of Regulators of Polyploidization Presents  Therapeutic Targets for Treatment of AMKL.
    Cell. 2012 Aug 3;150(3):575-89. PubMed PMID: 22863010.
  • Quivoron C, Couronné L, Della Valle V, Lopez CK, Plo I, Wagner-Ballon O, Do Cruzeiro M, Delhommeau F, Arnulf B, Stern MH, Godley L, Opolon P, Tilly H, Solary E, Duffourd Y, Dessen P, Merle-Beral H, Nguyen-Khac F, Fontenay M, Vainchenker W, Bastard C, Mercher T, Bernard OA. TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis.
    Cancer Cell. 2011 Jun 29. [Epub ahead of print] PubMed PMID: 21723201.
  • Cornejo MG, Mabialah V, Sykes SM, Khandan T, Lo Celso C, Lopez C, Rivera-Muñoz P, Rameau P, Tothova Z, Aster JC, Depinho RA, Scadden DT, Gilliland DG, Mercher T. Crosstalk between Notch and AKT signaling during murine megakaryocyte lineage  specification.
    Blood. 2011 Jun 7. [Epub ahead of print] PubMed PMID: 21653327.
  • Mercher T, Raffel GD, Moore SA, Cornejo MG, Baudry-Bluteau D, Cagnard N, Jesneck JL, Pikman Y, Cullen DE, Williams IR, Akashi K, Shigematsu H, Bourquin JP, Giovannini M, Vainchenker W, Levine RL, Lee BH, Bernard OA, Gilliland DG. OTT-MAL activates RBPJ transcription and induces acute megakaryoblastic leukemia in a knock-in mouse model.
    J Clin Invest. 2009 Apr;119(4):852-64. doi: 10.1172/JCI35901.
  • Cornejo MG, Kharas MG, Werneck MB, Le Bras S, Moore SA, Ball B, Beylot-Barry M, Rodig SJ, Aster JC, Lee BH, Cantor H, Merlio JP, Gilliland DG, Mercher T. Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplant models.
    Blood. 2009 Mar 19;113(12):2746-54.
  • Mercher T, Cornejo MG, Sears C, Kindler T, Moore SA, Maillard I, Pear WS, Aster JC, Gilliland DG. Notch signaling specifies megakaryocyte development from hematopoietic stem cells.
    Cell Stem Cell. 2008 Sep 11;3(3):314-26.
  • Walters DK*, Mercher T*, Gu TL*, O'Hare T, Tyner JW, Loriaux M, Goss VL, Lee KA, Eide CA, Wong MJ, Stoffregen EP, McGreevey L, Nardone J, Moore SA, Crispino J, Boggon TJ, Heinrich MC, Deininger MW, Polakiewicz RD, Gilliland DG, Druker BJ. Activating alleles of JAK3 in acute megakaryoblastic leukemia. *: equal contribution.
    Cancer Cell. 2006 Jul;10(1):65-75.
  • Mercher, T., Coniat, M.B., Monni, R., Mauchauffe, M., Khac, F.N., Gressin, L., Mugneret, F., Leblanc, T., Dastugue, N., Berger, R. and Bernard, O.A. (2001) Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia.
    Proc Natl Acad Sci USA, 98, 5776-5779.

 Patent

Title: Methods for the treatment of anaplastic large cell lymphoma
Reference: BIO21072 BRUNET / MC/BTL
Date of submission: April 9th 2021
Status: co-inventor

 

 

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