Integrative Tumour Immunology and Genetic Oncology
One-team unit UMR 1186.
The research activities of INSERM unit U1186 are focused on lung cancer, melanoma and renal cell carcinoma (RCC). Its project is articulated around three main themes developed by three groups with the aim of integrating tumor immunology and tumor biology in the future innovative immunotherapy approaches and targeted therapies.
Theme 1: Tumor antigens and T-cell reactivity
Leader: Fathia Mami-Chouaib
The program of this group aims at:
- further investigating the role of tissue-resident memory T cells (TRM) in antitumor T-cell immunity and response to cancer immunotherapy
- elucidating the influence of CD103 integrin in regulating intratumoral TRM migration and effector functions in pulmonary tumor
- developing a novel active immunotherapy approach for lung cancer based on the preprocalcitonin (ppCT) tumor antigen
The latter research axis has led to the foundation of a startup, ElyssaMed.
Theme 2: Impact of tumor microenvironment on tumor resistance and its role in shaping tumor plasticity and stroma reactivity
Leader: Salem Chouaib
The activity of this group is concentrated on:
- investigating the nontranscriptional function of p53 in regulating cell death and cancer-associated fibroblasts (CAF) functions
- elucidating the impact of hypoxic stress on tumor plasticity and immune heterogeneity
- understanding the interaction between MITF and hypoxia in the control of melanoma progression and identification of biomarkers of tumor invasion
- developing a translational research around the anti-leukemic potential of NK cells in acute myelogenous leukemia (AML)
With, in this theme, the ATIP/AVENIR team led by Mehdi Khaled "Oncogenesis and tumor progression of melanoma"
Theme 3: Genetics and biology of renal cell carcinoma
Leader: Stéphane Richard
The research project of this group aims at:
- searching new mutated genes responsible for unexplained familial RCC syndromes by next generation sequencing on germline DNA
- understanding the physiopathology of inherited RCC using a functional genetic approach
- characterizing genomic profiles of hereditary and sporadic RCC