Lab members

• Salem Chouaib (DRE, Inserm)
• Jerome Thiery (CRCN, Inserm)
• Pierre Savagner (CRCN, CNRS)
• Laurence Albiges (PH, Gustave Roussy)
• Jean-Henri Bourhis (PH, Gustave Roussy)
• Jean-Paul Thiery (DR emeritus, CNRS)
• Stephane Terry (Post-Doctoral fellow, Gustave Roussy)
• Stephanie Buart (Engineer, Inserm)
• Abderemane Abdou (Technician, Inserm)
• Marie Chollat-Namy (PhD candidate, University Paris-Saclay)
• Flora Doffe (PhD candidate, University Paris-Saclay)

Major publications

• Noman MZ, Desantis G, Janji B, Hasmim M, Karray S, Dessen P, Bronte V, Chouaib S. PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J Exp Med. 2014 May 5;211(5):781-90.
• Noman MZ, Janji B, Hu S, Wu JC, Martelli F, Bronte V, Chouaib S. Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210. Cancer Res. 2015 Sep 15;75(18):3771-87

Impact of tumor microenvironment on tumor resistance and its role in shaping tumor plasticity and stroma reactivity

This group belongs to the UMR 1186 - Integrative tumor immunology and immunotherapy

Lab members

• Karim Fizazi (PU-PH Univ. Paris-Saclay)
• Yohann Loriot (MD-PhD, GR)
• Anne Chauchereau (CRCN-HDR INSERM)
• Virginie Quidville (Research Engineer, GR)
• Déborah Bellet (Chargée d’études, GR)
• Ludovic Bigot (Engineer, GR)
• Sandrine Agoussi (Technician, GR)
• Jonathan Sabio (Technician, GR)
• Guiseppina Claps (Post-Doctoral fellow, GR)
• Ramdane Guemiri (Post-Doctoral fellow, GR)
• Shensi Shen (Post-Doctoral fellow, GR)
• Michaël Cerezo (Post-Doctoral fellow, GR)

Major publications

• Shen S et al. An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells. Nat Commun. 2019; 10(1):5713.
• Cerezo M, Guemiri R et al. Translational control of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma Nat Med. 2018 (12):1877-1886

Non genomic adaptation to anticancer therapies

This team belongs to the UMR 981 - Molecular predictors and new targets in oncology

Lab members

• Ken Olaussen (MCU Univ. Paris-Saclay, HDR)
• Françoise Farace (Ingénieure IGR, HDR)
• Benjamin Besse (PU-PH Univ. Paris-Saclay)
• Christophe Massard (PU-PH Univ. Paris-Saclay)
• David Planchard (MD IGR)
• Patrycja Pawlikowska (Ingénieure de recherche IGR)
• Floriane Brayé (Ingénieure d’études IGR)
• Marianne Oulhen (Ingénieure d’études IGR)
• Pauline Tesson (Technicienne IGR)
• Agathe Aberlenc (Technicienne IGR)
• Natalia Pinzon (Post-Doctorante IGR)