Translational Cancer Genomics

Translational Cancer Genomics - Major publications

• Yoann Pradat, Julien Viot, Andrey Yurchenko, Konstantin Gunbin, Luigi Cerbone, Marc Deloger, Guillaume Grisay, Loic Verlingue, Véronique Scott, Ismael Padioleau, Leonardo Panunzi, Stefan Michiels Antoine Hollebecque, Gérôme Jules-Clément, Laura Mezquita, Antoine Lainé, Yohann Loriot, Benjamin Besse, Luc Friboulet, Fabrice André, Paul-Henry Cournède, Daniel Gautheret, Sergey I Nikolaev. Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancer. Cancer Discov (2023) 13 (5): 1116–1143.
• Andrey A Yurchenko, Fatemeh Rajabi, Tirzah Braz-Petta, Hiva Fassihi, Alan Lehmann, Chikako Nishigori, Jinxin Wang, Ismael Padioleau, Konstantin Gunbin, Leonardo Panunzi, Fanny Morice-Picard, Pierre Laplante, Caroline Robert, Patricia L Kannouche, Carlos FM Menck, Alain Sarasin, Sergey I Nikolaev. Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients. Nature Communications. volume 14, 2561 (2023).
• Andrey A Yurchenko, Brice Fresneau, Bruno Borghese, Fatemeh Rajabi, Zora Tata, Catherine Genestie, Alain Sarasin, Sergey I Nikolaev. Early-onset gynecological tumors in DNA repair-deficient xeroderma pigmentosum group C patients: a case series. Communications Medicine volume 3, Article number: 109 (2023)
• Andrey A Yurchenko, Oltin T Pop, Meriem Ighilahriz, Ismael Padioleau, Fatemeh Rajabi, Hayley J Sharpe, Nicolas Poulalhon, Brigitte Dreno, Amir Khammari, Marc Delord, Antonio Alberdi, Nadem Soufir, Maxime Battistella, Samia Mourah, Fanny Bouquet, Ariel Savina, Andrej Besse, Max Mendez-Lopez, Florent Grange, Sandrine Monestier, Laurent Mortier, Nicolas Meyer, Caroline Dutriaux, Caroline Robert, Philippe Saïag, Florian Herms, Fred de Sauvage, Nicolas Dumaz, Lukas Flatz, Nicole Basset-Seguin, Sergey I Nikolaev. Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma. Clinical Cancer Research.2022. DOI: 10.1158/1078-0432.CCR-21-3764
• Andrey A Yurchenko, Ismael Padioleau, Bakhyt T Matkarimov, Jean Soulier, Alain Sarasin, Sergey Nikolaev. XPC deficiency increases risk of hematologic malignancies through mutator phenotype and characteristic mutational signature. Nat Commun. 2020 Nov 17;11(1):5834. doi: 10.1038/s41467-020-19633-9.
• Ximena Bonilla, Laurent Parmentier, Bryan King, Fedor Bezrukov, Gürkan Kaya, Vincent  Zoete, Vladimir B. Seplyarskiy, Hayley J. Sharpe, Thomas McKee, Audrey Letourneau,  Pascale G. Ribaux, Konstantin Popadin, Nicole Basset-Seguin, Rouaa Ben Chaabene, Maria  A. Andrianova, Michel Guipponi1, Marco Garieri, Carole Verdan, Kerstin Grosdemange,  Olga Sumara, Martin Eilers, Iannis Aifantis, Olivier Michielin, Frederic J. de Sauvage, Stylianos E. Antonarakis, Sergey I. Nikolaev. Genomic analysis identifies novel drivers and progression pathways in skin basal cell carcinoma. Nature Genetics. 48(4):398-406, 2016.
• Ryan Carr, Denis Vorobyev,  Terra Lasho, David Marks,  Ezequiel Tolosa, Alexis Vedder, Luciana Almada, Andrey Yurchenko, Ismael Padioleau, Bonnie Alver, Giacomo Coltro, Moritz Binder, Stephanie Safgren, Isaac Horn, Xiaona You,  Nathalie Droin,  Eric Solary, Maria Balasis, Kurt Berger, Christopher Pin, Thomas Witzig, Ajinkya Buradkar, Mr. Ryan Carr,  Peter Valent, Abhishek Mangaonkar, Keith Robertson, Matthew Howard,  Scott Kaufmann, Martin Fernandez-Zapico, Klaus Geissler,  Eric Padron, Jing Zhang,  Sergey Nikolaev*, Mrinal Patnaik*. RAS mutations drive proliferative chronic myelomonocytic leukemia via a novel KMT2A-PLK1 axis. Nat Commun. 2021. DOI: 10.1038/s41467-021-23186-w
• Sergey I Nikolaev, Sandra Vetiska, Ximena Bonilla, Emilie Boudreau, Suvi Jauhiainen, Behnam Rezai Jahromi, Nadiya Khyzha, Peter DiStefano, Santeri Suutarinen, Tim-Rasmus Kiehl, Vitor Mendes Pereira, Timo Krings, Hugo Andrade-Barazarte, Takyee Tung, Taufik Valiante, Gelareh Zadeh, Mike Tymianski, Tuomas Rauramaa, Seppo Ylä-Herttuala, Stylianos E. Antonarakis, Joshua D. Wythe, Juhana Frösen, Jason E. Fish, Ivan Radovanovic. Somatic activating KRAS mutations in brain arteriovenous malformations. N Engl J Med N Engl J Med. 2018 Jan 3.
• Seplyarskiy, Vladimir B; Soldatov, Ruslan A; Popadin, Konstantin Y; Antonarakis, Stylianos E; Bazykin, Georgii A; Nikolaev, Sergey I. APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication. Genome research, 26(2):174-82,2016
• Nikolaev, Sergey I; Rimoldi, Donata; Iseli, Christian; Valsesia, Armand; Robyr, Daniel; Gehrig, Corinne; Harshman, Keith; Guipponi, Michel; Bukach, Olesya; Zoete, Vincent; Olivier Michielin, Katja Muehlethaler, Daniel Speiser, Jacques S. Beckmann, Ioannis Xenarios, Thanos D. Halazonetis, Victor Jongeneel, Bryan J. Stevenson, Stylianos E. Antonarakis. Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. Nature genetics, 44,2,133-139,2012

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