Exposome, Inheritance, Cancer and Health

Group leader
Gianluca Severi

Operational direction
Pascale Gerbouin-Rérolle - 01 42 11 60 98

Espace Maurice Tubiana, Level -1

Frise Banner: 
Exposome, Inheritance, Cancer and Health


By October 2022, data from the E3N-E4N cohort have contributed to the publication of more than 250 scientific papers.

Here is a selection of 20 recent key papers published by the Exposome and Heredity team (post 2010):

  • Canonico M, Artaud F, Degaey I, Moisan F, Kabore R, Portugal B, Nguyen TTH, Pesce G, Boutron-Ruault MC, Roze E, Elbaz A. Incidence of Parkinson's disease in French women from the E3N cohort study over 27 years of follow-up. Eur J Epidemiol. 2022 May;37(5):513-523.
  • Marques C,  Fiolet T, Frenoy P, Severi G, Mancini FR. Association between polycyclic aromatic hydrocarbons (PAH) dietary exposure and mortality risk in the E3N cohort. Sci Total Environ. 2022 Sep 20;840:156626.
  • Mancini FR, Frenoy P, Fiolet T, Fagherazzi G, Crépet A. Identification of chemical mixtures to which women are exposed through the diet: Results from the French E3N cohort. Environ Int. 2021 Jul;152:106467.
  • MacDonald CJ, Madika AL, Bonnet F, Fagherazzi G, Lajous M, Boutron-Ruault MC. Consumption of cocoa-containing foods and risk of hypertension in French women. Eur J Epidemiol. 2020 May;35(5):465-469.
  • Fagherazzi G, El Fatouhi D, Fournier A, Gusto G, Mancini FR, Balkau B, Boutron-Ruault MC, Kurth T, Bonnet F. Associations Between Migraine and Type 2 Diabetes in Women: Findings From the E3N Cohort Study. JAMA Neurol. 2019 Mar 1;76(3):257-263.
  • Ongono JS, Dow C, Gambaretti J, Severi G, Boutron-Ruault MC, Bonnet F, Fagherazzi G, Mancini FR. Dietary exposure to brominated flame retardants and risk of type 2 diabetes in the French E3N cohort. Environ Int. 2019 Feb;123:54-60.
  • Touillaud M, Gelot A, Mesrine S, Bennetau-Pelissero C, Clavel-Chapelon F, Arveux P, Bonnet F, Gunter M, Boutron-Ruault MC, Fournier A. Use of dietary supplements containing soy isoflavones and breast cancer risk among women aged >50 y: a prospective study. Am J Clin Nutr. 2019 Mar 1;109(3):597-605.
  • Mancini FR, Affret A, Dow C, Balkau B, Bonnet F, Boutron-Ruault MC, Fagherazzi G. Dietary antioxidant capacity and risk of type 2 diabetes in the large prospective E3N-EPIC cohort. Diabetologia. 2018 Feb;61(2):308-316.
  • Fournier A, Mesrine S, Gelot A, Fagherazzi G, Baglietto L, Clavel-Chapelon F, Boutron-Ruault MC, Chabbert-Buffet N. Use of Bisphosphonates and Risk of Breast Cancer in a French Cohort of Postmenopausal Women. J Clin Oncol. 2017 Oct 1;35(28):3230-3239.
  • Bastide N, Morois S, Cadeau C, Kangas S, Serafini M, Gusto G, Dossus L, Pierre FH, Clavel-Chapelon F, Boutron-Ruault MC. Heme iron intake, dietary antioxidant capacity, and risk of colorectal adenomas in a large cohort study of French women. Cancer Epidemiol Biomarkers Prev. 2016 Apr;25(4):640-7.
  • Lajous M, Rossignol E, Fagherazzi G, Perquier F, Scalbert A, Clavel-Chapelon F, Boutron-Ruault MC. Flavonoid intake and incident hypertension in women. Am J Clin Nutr. 2016 Apr;103(4):1091-8.
  • Fasanelli F, Baglietto L, Ponzi E, Guida F, et al. Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts. Nat Commun. 2015 Dec 15;6:10192.
  • Moisan F, Spinosi J, Delabre L, Gourlet V, Mazurie JL, Bénatru I, Goldberg M, Weisskopf MG, Imbernon E, Tzourio C, Elbaz A. Association of Parkinson's Disease and Its Subtypes with Agricultural Pesticide Exposures in Men: A Case-Control Study in France. Environ Health Perspect. 2015 Nov;123(11):1123-9.
  • Cadeau C, Fournier A, Mesrine S, Clavel-Chapelon F, Fagherazzi G, Boutron-Ruault MC. Interaction between current vitamin D supplementation and menopausal hormone therapy use on breast cancer risk: evidence from the E3N cohort. Am J Clin Nutr. 2015 Oct;102(4):966-73.
  • Kvaskoff M, Bijon A, Mesrine S, Vilier A, Baglietto L, Fournier A, Clavel-Chapelon F, Dossus L, Boutron-Ruault MC. Association between melanocytic nevi and risk of breast diseases: The French E3N prospective cohort. PLoS Med. 2014 Jun 10;11(6):e1001660.
  • Lajous M, Bijon A, Fagherazzi G, Rossignol E, Boutron-Ruault MC, Clavel-Chapelon F. Processed and unprocessed red meat consumption and hypertension in women. Am J Clin Nutr. 2014 Sep;100(3):948-52.
  • Artaud F, Dugravot A, Sabia S, Singh-Manoux A, Tzourio C, Elbaz A. Unhealthy behaviours and disability in older adults: three-City Dijon cohort study. BMJ. 2013 Jul 23;347:f4240.
  • Dossus L, Kvaskoff M, Bijon A, Engel P, Verdebout J, Fervers B, Boutron-Ruault MC, Clavel-Chapelon F, Mesrine S. Latitude and ultraviolet radiation dose in the birthplace in relation to menarcheal age in a large cohort of French women. Int J Epidemiol. 2013 Apr;42(2):590-600.
  • Fagherazzi G, Vilier A, Saes Sartorelli D, Lajous M, Balkau B, Clavel-Chapelon F. Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidemiologique aupres des femmes de la Mutuelle Generale de l'Education Nationale-European Prospective Investigation into Cancer and Nutrition cohort. Am J Clin Nutr. 2013 Mar;97(3):517-23.
  • Morois S, Mesrine S, Besemer F, Josset M, Clavel-Chapelon F, Boutron-Ruault MC. Risks of colon and rectal adenomas are differentially associated with anthropometry throughout life: the French E3N prospective cohort. Int J Epidemiol. 2011 Oct;40(5):1269-79.
  • Jantchou P, Morois S, Clavel-Chapelon F, Boutron-Ruault MC, Carbonnel F. Animal Protein Intake and Risk of Inflammatory Bowel Disease: The E3N Prospective Study. Am J Gastroenterol. 2010 Oct;105(10):2195-201.


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