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GUSTAVE ROUSSY
1er centre de lutte contre le cancer en Europe, 4 000 professionnels mobilisés

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Se rendre à Gustave Roussy

Exposome, Hérédité, Cancer et Santé

Directeur
Gianluca Severi

Directeur adjoint
Alexis Elbaz

Direction opérationnelle
Pascale Gerbouin-Rérolle - 01 42 11 60 98

Pendant les travaux de construction du futur pavillon de recherche, l’équipe est hébergée à l’Hôpital Paul Brousse de Villejuif.

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Exposome, Hérédité, Cancer et Santé

Publications

Depuis le lancement de l’étude E3N et avec celui de la cohorte familiale E3N-Générations, plus de 1 400 articles scientifiques ont été publiés par l’équipe : 275 sont issus exclusivement des données des cohortes E3N et E3N-Générations, les autres sont le fruit de collaborations nationales ou internationales.

Voici une sélection d’une trentaine de publications significatives récentes (après 2010) de l’équipe Exposome et Hérédité :

  • Chetrit L, Frenoy P, Artaud F, Marques C, Ren X, Severi G, Mancini FR. Evidence of a positive association between dietary exposure to polychlorinated biphenyl (PCB) and weight gain among women in the E3N prospective cohort. Sci Total Environ. 2024 Dec 20;957:177587.
  • Domenighetti C, Sugier PE, Ashok Kumar Sreelatha A, Schulte C, Grover S, Portugal B, Lee PC, (...), Elbaz A; Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (COURAGE-PD) Consortium. Association of Body Mass Index and Parkinson Disease: A Bidirectional Mendelian Randomization Study. Neurology. 2024 Aug 13;103(3):e209620.
  • Marques C, Frenoy P, Elbaz A, Laouali N, Shah S, Severi G, Mancini FR. Association between dietary intake of acrylamide and increased risk of mortality in women: Evidence from the E3N prospective cohort. Sci Total Environ. 2024 Jan 1;906:167514.
  • Fournier A, Cairat M, Severi G, Gunter MJ, Rinaldi S, Dossus L. Use of menopausal hormone therapy and ovarian cancer risk in a French cohort study. J Natl Cancer Inst. 2023 Jun 8;115(6):671-679.
  • Nguyen TTH, Fournier A, Courtois É, Artaud F, Escolano S, Tubert-Bitter P, Boutron-Ruault MC, Degaey I, Roze E, Canonico M, Ahmed I, Thiébaut ACM, Elbaz A. Statin Use and Incidence of Parkinson's Disease in Women from the French E3N Cohort Study. Mov Disord. 2023 May;38(5):854-865.
  • Pesce G, Artaud F, Roze E, Degaey I, Portugal B, Nguyen TTH, Fournier A, Boutron-Ruault MC, Severi G, Elbaz A, Canonico M. Reproductive characteristics, use of exogenous hormones and Parkinson disease in women from the E3N study. Brain. 2023 Jun 1;146(6):2535-2546.
  • Portugal B, Artaud F, Degaey I, Roze E, Fournier A, Severi G, Canonico M, Proust-Lima C, Elbaz A. Association of Physical Activity and Parkinson Disease in Women: Long-term Follow-up of the E3N Cohort Study. Neurology. 2023 Jul 25;101(4):e386-e398.
  • Portugal B, Artaud F, Domenighetti C, Roze E, Degaey I, Canonico M, Elbaz A. Body Mass Index, Abdominal Adiposity, and Incidence of Parkinson Disease in French Women From the E3N Cohort Study. Neurology. 2023 Jan 17;100(3):e324-e335.
  • Canonico M, Artaud F, Degaey I, Moisan F, Kabore R, Portugal B, Nguyen TTH, Pesce G, Boutron-Ruault MC, Roze E, Elbaz A. Incidence of Parkinson's disease in French women from the E3N cohort study over 27 years of follow-up. Eur J Epidemiol. 2022 May;37(5):513-523.
  • Fiolet T, Casagrande C, Nicolas G, Horvath Z, Frenoy P, Weiderpass E, Katzke V, Kaaks R, Rodriguez-Barranco M, Panico S, Sacerdote C, Manjer J, Sonestedt E, Grioni S, Agudo A, Rylander C, Haugdahl Nøst T, Skeie G, Tjønneland A, Raaschou-Nielsen O, Ardanaz E, Amiano P, Dolores Chirlaque López M, Schulze MB, Wennberg M, Harlid S, Cairat M, Kvaskoff M, Huybrechts I, Mancini FR. Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and breast cancer risk in 9 European countries. Environ Int. 2022 May;163:107213.
  • Frenoy P, Marques C, Fiolet T, Cano-Sancho G, Severi G, Mancini FR. Positive association between dietary exposure to polybrominated diphenyl ethers and breast cancer risk in the French E3N cohort: The role of vegetable oil consumption. Environ Int. 2022 Sep;167:107444.
  • Marques C,  Fiolet T, Frenoy P, Severi G, Mancini FR. Association between polycyclic aromatic hydrocarbons (PAH) dietary exposure and mortality risk in the E3N cohort. Sci Total Environ. 2022 Sep 20;840:156626.
  • Mancini FR, Frenoy P, Fiolet T, Fagherazzi G, Crépet A. Identification of chemical mixtures to which women are exposed through the diet: Results from the French E3N cohort. Environ Int. 2021 Jul;152:106467.
  • MacDonald CJ, Madika AL, Bonnet F, Fagherazzi G, Lajous M, Boutron-Ruault MC. Consumption of cocoa-containing foods and risk of hypertension in French women. Eur J Epidemiol. 2020 May;35(5):465-469.
  • Fagherazzi G, El Fatouhi D, Fournier A, Gusto G, Mancini FR, Balkau B, Boutron-Ruault MC, Kurth T, Bonnet F. Associations Between Migraine and Type 2 Diabetes in Women: Findings From the E3N Cohort Study. JAMA Neurol. 2019 Mar 1;76(3):257-263.
  • Ongono JS, Dow C, Gambaretti J, Severi G, Boutron-Ruault MC, Bonnet F, Fagherazzi G, Mancini FR. Dietary exposure to brominated flame retardants and risk of type 2 diabetes in the French E3N cohort. Environ Int. 2019 Feb;123:54-60.
  • Touillaud M, Gelot A, Mesrine S, Bennetau-Pelissero C, Clavel-Chapelon F, Arveux P, Bonnet F, Gunter M, Boutron-Ruault MC, Fournier A. Use of dietary supplements containing soy isoflavones and breast cancer risk among women aged >50 y: a prospective study. Am J Clin Nutr. 2019 Mar 1;109(3):597-605.
  • Mancini FR, Affret A, Dow C, Balkau B, Bonnet F, Boutron-Ruault MC, Fagherazzi G. Dietary antioxidant capacity and risk of type 2 diabetes in the large prospective E3N-EPIC cohort. Diabetologia. 2018 Feb;61(2):308-316.
  • Fournier A, Mesrine S, Gelot A, Fagherazzi G, Baglietto L, Clavel-Chapelon F, Boutron-Ruault MC, Chabbert-Buffet N. Use of Bisphosphonates and Risk of Breast Cancer in a French Cohort of Postmenopausal Women. J Clin Oncol. 2017 Oct 1;35(28):3230-3239.
  • Bastide N, Morois S, Cadeau C, Kangas S, Serafini M, Gusto G, Dossus L, Pierre FH, Clavel-Chapelon F, Boutron-Ruault MC. Heme iron intake, dietary antioxidant capacity, and risk of colorectal adenomas in a large cohort study of French women. Cancer Epidemiol Biomarkers Prev. 2016 Apr;25(4):640-7.
  • Lajous M, Rossignol E, Fagherazzi G, Perquier F, Scalbert A, Clavel-Chapelon F, Boutron-Ruault MC. Flavonoid intake and incident hypertension in women. Am J Clin Nutr. 2016 Apr;103(4):1091-8.
  • Fasanelli F, Baglietto L, Ponzi E, Guida F, et al. Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts. Nat Commun. 2015 Dec 15;6:10192.
  • Moisan F, Spinosi J, Delabre L, Gourlet V, Mazurie JL, Bénatru I, Goldberg M, Weisskopf MG, Imbernon E, Tzourio C, Elbaz A. Association of Parkinson's Disease and Its Subtypes with Agricultural Pesticide Exposures in Men: A Case-Control Study in France. Environ Health Perspect. 2015 Nov;123(11):1123-9.
  • Cadeau C, Fournier A, Mesrine S, Clavel-Chapelon F, Fagherazzi G, Boutron-Ruault MC. Interaction between current vitamin D supplementation and menopausal hormone therapy use on breast cancer risk: evidence from the E3N cohort. Am J Clin Nutr. 2015 Oct;102(4):966-73.
  • Kvaskoff M, Bijon A, Mesrine S, Vilier A, Baglietto L, Fournier A, Clavel-Chapelon F, Dossus L, Boutron-Ruault MC. Association between melanocytic nevi and risk of breast diseases: The French E3N prospective cohort. PLoS Med. 2014 Jun 10;11(6):e1001660.
  • Lajous M, Bijon A, Fagherazzi G, Rossignol E, Boutron-Ruault MC, Clavel-Chapelon F. Processed and unprocessed red meat consumption and hypertension in women. Am J Clin Nutr. 2014 Sep;100(3):948-52.
  • Artaud F, Dugravot A, Sabia S, Singh-Manoux A, Tzourio C, Elbaz A. Unhealthy behaviours and disability in older adults: three-City Dijon cohort study. BMJ. 2013 Jul 23;347:f4240.
  • Dossus L, Kvaskoff M, Bijon A, Engel P, Verdebout J, Fervers B, Boutron-Ruault MC, Clavel-Chapelon F, Mesrine S. Latitude and ultraviolet radiation dose in the birthplace in relation to menarcheal age in a large cohort of French women. Int J Epidemiol. 2013 Apr;42(2):590-600.
  • Fagherazzi G, Vilier A, Saes Sartorelli D, Lajous M, Balkau B, Clavel-Chapelon F. Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidemiologique aupres des femmes de la Mutuelle Generale de l'Education Nationale-European Prospective Investigation into Cancer and Nutrition cohort. Am J Clin Nutr. 2013 Mar;97(3):517-23.
  • Morois S, Mesrine S, Besemer F, Josset M, Clavel-Chapelon F, Boutron-Ruault MC. Risks of colon and rectal adenomas are differentially associated with anthropometry throughout life: the French E3N prospective cohort. Int J Epidemiol. 2011 Oct;40(5):1269-79.
  • Jantchou P, Morois S, Clavel-Chapelon F, Boutron-Ruault MC, Carbonnel F. Animal Protein Intake and Risk of Inflammatory Bowel Disease: The E3N Prospective Study. Am J Gastroenterol. 2010 Oct;105(10):2195-201.
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