Physiology and Molecular Pathology of Endogenous and Infectious Retroviruses

This Research Unit is composed of the "Physiology and Molecular Pathology of Endogenous and Infectious Retroviruses" team.

The Unit's work, historically focused on retroelements and retroviruses, has made significant contributions to:

Lab members

• Fathia Mami-Chouaib (DR1 INSERM): group leader
• Pascale Leroy (CRCN, CNRS)
• Julien Adam (PH, IGR)
• Stéphanie Corgnac (Post-Doc, IGR)
• Marine Leclerc (Post-Doc, IGR)
• Inès Malenica (Post-Doc, INSERM)
• Isabelle Tihy (PhD student, Paris XI)
• Gwendoline Gros (AI, INSERM)
• Jamila Kacher (IE, CDD, INSERM)
• Laetitia Grynszpan (TCN, CDD, IGR)
• Vincent de Montpreville (PH, Centre Chirurgical Marie Lannelongue)
• Clara Coelho Basto (M2, Paris XI)

Major publications

1. DJENIDI F, ADAM J, GOUBAR A, DURGEAU A, MEURICE G, DE MONTPREVILLE V, VALIDIRE P, BESSE B and MAMI-CHOUAIB F. CD8⁺/CD103⁺ tumor-infiltrating lymphocytes are tumor-specific tissue-resident memory T cells and a prognostic factor for survival in lung cancer patients. J Immunol. 2015 Apr 1;194(7):3475-86.

Many associations bring happiness and hope to children and parents:

• Leisure activities and package breaks for patients
• Regular presence
• Support and help in the development of programmes across the Department  
• Financial support for research projects and work on a human scale
• Financial support for the project « Poussons les murs » (Let’s push back the walls)

Plastic Arts workshop

This is focussed on teaching children to use the language of art to express themselves through painting, drawing, collage, photography and sculpture. This aids the child to resume contact with their senses and emotions.  
This is conducted by a plastic arts teacher who is on site on Tuesday, Wednesday and Thursday. 

Education as a vector of socialisation

It is fundamentally important to maintain educational continuity for all these young patients. This continuity is supplied both within and outside Gustave Roussy thanks to a teaching team composed of teachers from the National Education system and volunteer teachers who are members of the « School in the Hospital » charitable association. The team is involved in and conscious of the specific needs of these pupils.

The long-term follow-up clinic

3 million individuals aged over 15 years have had cancer at some time during their life, which represents 6% of the French population in that age group. At present, there are 25,000 adult survivors of childhood cancer in France. 75% of these have severe or incapacitating symptoms 35 years later.

Paediatric oncology long-term follow-up has, therefore, a major role: