Doctor Philippe Gorphe

Dr Gorphe is a surgeon specialising in otorhinolaryngology and cervicofacial surgery, working in the cervicofacial oncology department at Gustave Roussy.

Lab members

• Nazanine Modjtahedi, DR2, CNRS, team leader
• Lluis M Mir, DRCE, CNRS
• Catherine Brenner, DR2, CNRS
• Franck M André, CRCN, CNRS
• Giorgia Urbinati, CRCN, CNRS
• Jean-Remi Bertrand, IR, INSERM
• Alain Deroussent, IR, CNRS
• Céline Gracia, IE, CNRS
• Dawei Liu, Post-doc, INCA/CNRS
• Camille Reinhardt, Post-doc, INCA/CNRS
• Thai -Hoa Chung, Doc, Université Paris-Saclay
• Amina Ghorbel, Doc, Université Paris-Saclay
• Kenza Nedara, Doc, Université Paris-Saclay

Major publications

• Reinhardt C, Arena G, Nedara K, Edwards R, Brenner C, Tokatlidis K, Modjtahedi N. AIF meets the CHCHD4/Mia40-dependnet mitochondrial import pathway. Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165746. doi: 10.1016/j.bbadis.2020.165746.
• Pervaiz S, Bellot G, Lemoine A, and Brenner C. Redox Signaling in the pathogenesis of human disease and the regulatory role of autophagy. Int Rev Cell Mol Biol. 2020, in press.

Metabolic plasticity in health and disease

This group belongs to the UMR 9018 - Metabolic and systemic aspects of oncogenesis for novel therapeutic approaches (Metsy)

DNA repair, chromatin remodeling and epigenetics
Lab members

• Roman Chabanon, post-doctorant
• Thomas Eychenne, post-doctorant
• Daphné Morel, Doctorante
• Clémence Hénon, Doctorante
• Carine Ngo, Doctorante,
• Asuka Kawai-Kawachi, ESMO Fellow
• Marlène Garrido, Ingénieure
• Nicolas Dorvault, Technicien
• Léo Colmet-Daage, bioinformaticien

DNA repair, chromatin remodeling and epigenetics
Major publications

1. Epigenetic drugs in solid tumours: lessons learned and future promises? Morel D, Jeffery D, Aspeslagh S, Almouzni G, Postel-Vinay S. Nature Reviews Clinical Oncology 2019 Sep 30. doi: 10.1038/s41571-019-0267-4 [Epub ahead of print]

DNA repair, chromatin remodeling and epigenetics

This team belongs to the UMR 981 - Molecular predictors and new targets in oncology.