Impact of tumor microenvironment on tumor resistance and its role in shaping tumor plasticity and stroma reactivity

This group belongs to the UMR 1186 - Integrative tumor immunology and immunotherapy

Laboratory of Translational Research in Immunotherapy (LRTI)

CD8 T-cell immunity and immunotherapy in lung cancer

This group belongs to the UMR 1186 - Integrative tumor immunology and immunotherapy

Despite advances in immunotherapy, a large fraction of cancer patients fails to respond. Immune mechanisms behind this resistance are poorly elucidated. The objective of our research program is to comprehensively characterize and study the role of a new class of white blood cells, called resident memory T cells (TRM), in antitumor immunity and response to cancer immunotherapy.

"Metabolism, cancer and immunity" group

This laboratory belongs to the UMR S1138 - Centre de Recherche des Cordeliers.

Oncogenesis and tumour progression of melanoma group

This group belongs to the UMR 1279 - Tumor cell dynamics

In our group we are studying in parrallel:

• The biology of melanocytes which are pigment producing cells responsible for skin color
• The biology of cutaneous melanoma, which derives fromm melanocytes.

Using a comprehensive approach, we strive to identify mutations responsible for melanoma transformation and genes involved in metastasis.

Tumour immunology and immunotherapy

Group 1 of the Inserm (National Institute of Health and Medical Research) UMR 1015 research unit, « Tumour immunology and immunotherapy of cancer », is under the direction of Professor Laurence Zitvogel.  Between 2015 and 2018 it will be exploring three lines of research: 
-    Gut microbiota and pro- or anti-tumour inflammatory/immunological activity, by measuring the effect of specific therapies on their regulation,