Lab members

• Nazanine Modjtahedi, DR2, CNRS, team leader
• Lluis M Mir, DRCE, CNRS
• Catherine Brenner, DR2, CNRS
• Franck M André, CRCN, CNRS
• Giorgia Urbinati, CRCN, CNRS
• Jean-Remi Bertrand, IR, INSERM
• Alain Deroussent, IR, CNRS
• Céline Gracia, IE, CNRS
• Dawei Liu, Post-doc, INCA/CNRS
• Camille Reinhardt, Post-doc, INCA/CNRS
• Thai -Hoa Chung, Doc, Université Paris-Saclay
• Amina Ghorbel, Doc, Université Paris-Saclay
• Kenza Nedara, Doc, Université Paris-Saclay

Major publications

• Reinhardt C, Arena G, Nedara K, Edwards R, Brenner C, Tokatlidis K, Modjtahedi N. AIF meets the CHCHD4/Mia40-dependnet mitochondrial import pathway. Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165746. doi: 10.1016/j.bbadis.2020.165746.
• Pervaiz S, Bellot G, Lemoine A, and Brenner C. Redox Signaling in the pathogenesis of human disease and the regulatory role of autophagy. Int Rev Cell Mol Biol. 2020, in press.

Metabolic plasticity in health and disease

This group belongs to the UMR 9018 - Metabolic and systemic aspects of oncogenesis for novel therapeutic approaches (Metsy)

DNA repair, chromatin remodeling and epigenetics
Lab members

• Roman Chabanon, post-doctorant
• Thomas Eychenne, post-doctorant
• Daphné Morel, Doctorante
• Clémence Hénon, Doctorante
• Carine Ngo, Doctorante,
• Asuka Kawai-Kawachi, ESMO Fellow
• Marlène Garrido, Ingénieure
• Nicolas Dorvault, Technicien
• Léo Colmet-Daage, bioinformaticien

DNA repair, chromatin remodeling and epigenetics
Major publications

1. Epigenetic drugs in solid tumours: lessons learned and future promises? Morel D, Jeffery D, Aspeslagh S, Almouzni G, Postel-Vinay S. Nature Reviews Clinical Oncology 2019 Sep 30. doi: 10.1038/s41571-019-0267-4 [Epub ahead of print]

DNA repair, chromatin remodeling and epigenetics

This team belongs to the UMR 981 - Molecular predictors and new targets in oncology.

Major publications

1: Dercle L, Ammari S, Roblin E, Bigorgne A, Champiat S, Taihi L, Plaian A, Hans S, Lakiss S, Tselikas L, Rouanne M, Deutsch E, Schwartz LH, Gönen M, Flynn J, Massard C, Soria JC, Robert C, Marabelle A. High serum LDH and liver metastases are the dominant predictors of primary cancer resistance to anti-PD(L)1 immunotherapy. Eur J Cancer. 2022 Dec;177:80-93. doi: 10.1016/j.ejca.2022.08.034. Epub 2022 Sep 30. PMID: 36332438.

Lab members

Françoise PORTEU - DR INSERM    
Eric SOLARY - PUPH
Nathalie DROIN - CR INSERM
Emilie ELVIRA-MATELOT - CR INSERM
Dorothée SELIMOGLU-BUET - CR (INSERM)
Lucie LAPLANE - CR CNRS
Aline RENNEVILLE, PH IGR
    
Richard DYUNGA - TR INSERM
Margot MORABITO - TR  (RP/IGR)
Séverine BADEL - TR (RP/IGR)
Margaux SEVIN - IR (RP/IGR)
        
 PELINSKI Yanis - Ph.D., University Paris Saclay
 Christophe WILLEKENS - Ph.D., University Paris Saclay
 Donia HIDAOUI - Ph.D., University Paris Saclay

Major publications

• Bencheikh L, Diop MK, Rivière J, Pierron G, Souquere S, Naimo A, Morabito M, Dussiot M, de Leeuw F, Solary E, Droin N. Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages. Nat Commun. 2019; 10(1):1935.