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UMR 1287 - Hematopoietic stem cells and the development of myeloid malignancies
At the apex of the hematopoietic tissue, hematopoietic stem cells (HSCs) self-renew and give rise to all blood cell lineages. The tightly regulated mechanisms involved in normal hematopoiesis include a number of intrinsic factors, such as transcription factors & epigenetic marks, and extrinsic factors such as surrounding cells of the niche and the cytokines they produce.
The Genome Integrity and Cancers unit focuses its efforts on understanding the molecular and cellular mechanisms that govern the stability of the genome, one of the major areas of research at the Gustave Roussy Institute.