Oncostat

This group is the Oncostat team of the UMR1018/CESP.

The Oncostat team develops methods for the evaluation of precision medicine in oncology based on the level of evidence.

U1355 – RAMO-IT -
Molecular Radiotherapy and Therapeutic Innovations

Transforming radiotherapy: toward precision medicine

Unit U1355/RAMO-IT (formerly “U1030”) develops an integrated research program aimed at profoundly transforming the use of radiotherapy in oncology. Historically based on standardized approaches, radiotherapy now faces major limitations related to the biological heterogeneity of tumors, variability in patient responses, and the occurrence of sometimes debilitating toxicities.

UMR 1186 - Integrative tumor immunology and immunotherapy

Our laboratory highlighted several constitutive elements of the tumor environment (TME) involved in the regulation of antitumor T-cell response, in particular:

Centre for research in epidemiology and population health

The Centre for Research in Epidemiology and Population Health (CESP) is one of the largest French centres for training and research in Public Health.   

It is linked to Inserm, the Paris-Saclay University and the University of Versailles Saint Quentin.

3 of the CESP groups are based on the Gustave Roussy site:

Lab members

• Brigitte Bressac de Paillerets, PhD, PharmD, Geneticist
• Aude Robert, PhD, Research engineer
• Justine Del Rio, Technician and lab manager
• Julia Gilaizeau, Technician
• Elisa Stubbs, PhD candidate
• Sophie Lachaud, PhD candidate
• Assaf Alassaf, M2
• Mélanie Bennaroch, Technician

Major publications

• Golan, T., Parikh, R., Jacob, E., Vaknine, H., Zemser-Werner, V., Hershkovitz, D., Malcov, H., Leibou, S., Reichman, H., Sheinboim, D., Percik, R., Amar, S., Brenner, R., Greenberger, S., Kung, A., Khaled, M., and Levy, C. (2019) Adipocytes sensitize melanoma cells to environmental TGF-beta cues by repressing the expression of miR-211. Sci Signal 12

Oncogenesis and tumour progression of melanoma group

This team belongs to the UMR 1279 - Tumor cell dynamics

In our group we are studying in parrallel:

• The biology of melanocytes which are pigment producing cells responsible for skin color
• The biology of cutaneous melanoma, which derives fromm melanocytes.

Using a comprehensive approach, we strive to identify mutations responsible for melanoma transformation and genes involved in metastasis.

Tumour Immunology and anti-cancer immunotherapy unit

This unit is an Inserm, Gustave Roussy and Paris-Saclay University Mixed Research Unit.

The unit "Tumour immunology and anti-cancer immunotherapy" consists of the following research teams:

UMR 981 - Molecular predictors and new targets in oncology

Directed by Prof.Fabrice André, this Mixed Research Unit (Inserm - Gustave Roussy - University of Paris Sud) is a multiple team unit:

UMR 1170 - Transcriptional and epigenetic control of Malignant Hematopoiesis