Xavier Renaudin, Jean-Hugues Guervilly, Said Aoufouchi, and Filippo Rosselli.Proteome-wide analysis unveils a FANCA-modulated neddylation signaling pathway involved in CXCR5 membrane trafficking and cell mobility.
Our group associates researchers working on the coordination and regulation of DNA repair processes in B lymphocyte following AID expression and on the role of AID in B cell tumourigenesis.
Sana Ahmed-Seghir, Caroline Pouvelle, Emmanuelle Despras, Agnès Cordonnier, Alain Sarasin and Patricia L Kannouche. Aberrant C-terminal Domain of Polymerase eta Targets the Functional Enzyme to the Proteosomal Degradation Pathway. DNA Repair, in revision.
Gustave Roussy's researchers and clinicians especially concentrate their work in the four main areas below, which combine basic research, clinical research, epidemiology and technology:
Molecular medicine – or personalised medicine, still called precision medicine, – is based on a new approach to diagnosis, known as molecular diagnosis, which depends on analysis of the tumour genome. According to the results of this analysis, targeted drugs tailored to the genetic profile are tried. The objective is to be able to offer each patient drugs which are specifically targeted to the genetic profile of the tumour.