Genome Plasticity and B cell

This group belongs to the group "TLS Polymerases: Genome Plasticity and Cancers" 

Our group associates researchers working on the coordination and regulation of DNA repair processes in B lymphocyte following AID expression and on the role of AID in B cell tumourigenesis. 

Lab members

• Patricia Kannouche (Directeur de recherche- CNRS), Manager
• Caroline Pouvelle (TCN CNRS)
• Emmanuelle Despras (Post-Doc GR)
• Sana Ahmed-Seguir (PhD student)
• Noémie Delrieu (PhD student, 4ème année ED Cancérologie, University Paris Sud)
• Yann Benureau (Engineer d’étude, GR- SIRIC)
• Mégane Bouvet (Technician, CDD-CNRS)
• Barbara Ben Yamin (Engineer assitant, CDD-CNRS)

Publications since 2008

• Sana Ahmed-Seghir, Caroline Pouvelle, Emmanuelle Despras, Agnès Cordonnier, Alain Sarasin and Patricia L Kannouche. Aberrant C-terminal Domain of Polymerase eta Targets the Functional Enzyme to the Proteosomal Degradation Pathway. DNA Repair, in revision.

Main research axes

Gustave Roussy's researchers and clinicians especially concentrate their work in the four main areas below, which combine basic research, clinical research, epidemiology and technology:

• Molecular Medicine
• Immunotherapy
• DNA Repair
• Rare Cancers

Molecular medicine

Molecular medicine – or personalised medicine, still called precision medicine, – is based on a new approach to diagnosis, known as molecular diagnosis, which depends on analysis of the tumour genome. According to the results of this analysis, targeted drugs tailored to the genetic profile are tried. The objective is to be able to offer each patient drugs which are specifically targeted to the genetic profile of the tumour.     

General Secretariat For Research

International Scientific Board

Gustave Roussy has renewed its Scientific Board in 2021, as well as the terms of its operation.

Research Directorate

Gustave Roussy brings together the skills required to develop integrated research on cancer, covering a large scale from exploratory research to clinical research, including expertise fields such as biology, imaging, epidemiology, biostatistics, data science, social and human sciences, and health economics.