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Until now, TREM2-expressing macrophages in a tumor were associated with a poor prognosis. Research conducted within Professor Florent Ginhoux's lab at Gustave Roussy, led by pathology resident Grégoire Gessain, shows that in head and neck squamous cell carcinomas (HNSCC), the presence of a specific type of immune cell—giant TREM2-expressing macrophages—is a marker of good prognosis. This new biomarker could assist oncologists in personalizing patient care.